12 
CIXCHOXIXE. 
A M/50 cinchonine solution was prepared by dissolving 2.94 gm. of 
the pure anhydrous alkaloid in N/2 HCl and using the same acid to 
make up the total volume to 500 cc. The results obtained with this 
solution are given in Tables I and II. 
Table I. 
Effect of the temperature of the water hath {90-95 C. ) on the stability of freshly-formed 
cinchonine hydrochloride . 
Time re- 
mained on 
water bath 
after com- 
plete evap- 
oration of 
liquid. 
M/50 cin- 
chonine 
taken. 
N/10 
NaOH 
required. 
X /10 1 
AgXOs ' 
required. 
Amount of 
HCl found .a 
Minutes. 
cc. 
cc. 
cc. 
Gram. 
30 
10 
4. 05 
4. 10 
0. 0148 
60 
10 
4. 00 
4. 04 
.0146 
90 
10 
4.00 
4.02 
.0146 
120 
10 
3. 95 
4.00 
.0144 
150 
10 
4. 00 
3. 98 
.0146 
180 
10 
4. 03 
4. 00 
.0147 
210 
10 
3. 98 
3. 96 
.0145 
* 240 
10 
4. 00 
3. 94 
.0146 
270 
10 
3. 95 
4. 00 
.0144 
300 
10 
4.02 
■ 4.00 
.0147 
330 
10 
3. 95 
3.98 
.0144 
360 
10 ■ 
4.00 
3.96 
.0146 
Amount of HCl theoretically required for C 19 H 22 N 2 O. 2HC1=0.0146. 
Table II. 
Effect of varying the amount of cinchonine on the constancy of the proportion of HCl in 
the alkaloidal residue. 
Temperature as in Table I; time, 3 hours. 
M/50 cin- 
chonine 
taken. 
X/10 XaOH 
required. 
N /10 AgXOs 
required. 
Ratio be- 
1 tween cc. 
cinchonine 
sol. taken 
1 and cc. N/10 
1 XaOH re- 
quired. 0 
cc. 
cc. 
cc. 
5 
2.00 
1.96 
2.50 
10 
3. 98 
3. 96 
2. 51 
20 
8. 10 
8. 04 
2. 47 
30 
12. 10 
11.94 
2.48 
40 
16. 15 
16. 10 
2. 48 
50 
^ J 
20 . 20 
20 . 06 
2. 48 
o All calculations were based on the results obtained on titration with the N/10 XaOH, 
