13 
QUIN I DINE. 
A M/50 quinidine solution was prepared by dissolving 3.24 gm. of 
the pure anhydrous alkaloid in N/2 HCl and using the same acid to 
make up the total volume to 500 cc. The results obtained with this 
solution are given in Tables III and IV. 
Table III. 
Effect of the temperature of the water bath (90-95 C.) on the stability of freshly-formed 
quinidine hydrochloride. 
1 Time re- 
1 mained on 
water bath 
after com- 
1 plete evap- 
1 oration of 
1 liquid. 
M/50 quini- 
dine taken. 
N/10 
NaOH 
required. 
N/10 
AgNOs 
required. 
Amount of 
HCl found. 
Minutes. 
cc. 
cc. 
cc. 
Gram. 
30 
10 
4. 08 
4. 04 
0. 0149 
60 
10 
4. 03 
4. 00 
.0147 
90 
10 
4.00 
3. 96 
. 0146 
120 
10 
4. 02 
3. 98 
.0147 
150 
10 
3. 98 
4. 06 
.0145 
180 
10 
4. 00 
3. 98 
.0146 
210 
10 
3. 95 
3. 98 
= 0144 
240 
10 
4. 02 
4. 04 
.0147 
270 
10 
4. 00 
4. 00 
.0146 
300 
10 
3. 95 
3. 96 
.0144 
330 
10 
4. 00 
3. 98 
.0146 
360 
10 
3. 98 
3.96 
.0145 
Amount of HCl theoreticallj^ required for C2oH24N2022HCl=0.0146. 
Table IV. 
Effect of larying the amount of quinidine on the constancy of the proportion of HCl in 
the alkaloidal residue. 
Temperature as in Table III; time, 3 hours. 
M/50 quini- 
dine taken. 
N/10 NaOH 
required. 
N/10 AgNOs 
required. 
Ratio be- 
tween cc. 
quinidine 
sol. taken 
and cc. N/10 
NaOH re- 
quired. 
cc. 
cc. 
cc. 
5 
1.95 
1.96 
2. 56 
10 
3. 95 
3. 90 
2.53 
20 
8.10 
7. 96 
2. 47 
30 
12. 15 
12. 16 
2. 47 
40 
16. 25 
16. 32 
2. 46 
50 
20. 28 
20. 36 
2. 47 
