u 
CIXCHOXIDIXE. 
A M/50 cinchonicline solution was prepared by dissolving 2.94 gm. 
of the pure anliydrous alkaloid in X/2 HCl (or X/2 acetic acid) and 
using the same acid to make up the total volume to 500 cc. The 
results obtained with these solutions are 2 :iven in Tables Y, M!, and 
VIT. 
Table V. 
Effect of the temperature of the v:aUr hath {90-95 C.) on the stability of freshly-formed 
cinchonidine hydrochloride. 
Time re- 
mained on 
water bath 
after com- 
plete evapo- 
ration of 
liquid. 
n 50 cin- 
chonidine 
taken. 
N/10 
XaOH 
required, j 
X 10 
AgXOs 
required. 
Amount of 
HCl found. 
Minutes. 
cc. 
cc. 
cc. 
Gram. I 
30 
10 
4.10 
4 06 
0. 0150 
60 
10 
408 
400 
• 01^9 
90 
10 
4.00 
3. 98 
.0146 
120 
10 
4 05 
4 00 
.0148 
1.50 
10 
3. 98 
4.00 
.0145 
ISO 
10 
403 
3.96 
.0147 
210 
10 
3. 95 
4 04 
.0144 
240 
10 
4 00 
4 02 
.0146 
270 
10 
400 
3. 96 
.0146 
300 
10 
3. 98 
3. 96 
.0145 
330 
10 
400 
3.98 
.0146 
360 
10 
3. 95 
400 
.0144 
Amount of HCl theoretically required for Ci9H22X2O.2HCl=0.0146. 
Table VI. 
Effect of varying the amount of cinchonidine on the constancy of the proportion of HCl 
in the alhaloidal residue. 
Temperature as in Table V; time, 3 hours. 
M 50 cin- 
chonidine 
taken. 
X/10 XaOH 
required. 
X. 10 AgXOs 
required. 
Ratio be- j 
tween cc. j 
cinchonidine 
sol. taken 
and cc. X 10 
XaOH re- 
quired. 
cc. 
cc. 
cc. 
5 
1.95 
1. 98 
2.56 
10 
403 
3. 96 
2.49 
20 
8.05 
S.OO 
2. 48 
30 
12. 15 
12. 16 
2. 47 
40 
16. 17 
16. 10 
2. 47 
50 
20. 25 
20. 18 
2.47 
1 
