15 
Table VII. 
Effect of the temperature of the water hath (90-95 C.) on the stability of freshly -formed 
cinchonidine acetate. 
Time re- 
mained on 
water bath 
after com- 
plete evapo- 
ration of 
liquid. 
M/50 cin- 
chonidine 
taken. 
N/10 
NaOH re- 
quired. 
Amount of 
acetic acid 
found. 
Minutes. 
cc. 
cc. 
Gram. 
30 
10 
3. 80 
0. 0228 
60 
10 
3. 33 
.0200 
90 
10 
3. 20 
.0192 
120 
10 
3. 03 
.0182 
150 
10 
3. 00 
.0180 
180 
10 
3. 00 
.0180 
210 
10 
2.85 
.0171 
240 
10 
2. 62 
.0157 
270 
10 
2. 60 
.0156 
300 
10 
2.33 
.0140 
330 
10 
2. 00 
.0120 
360 
10 
2. 15 
.0129 
Amount of C2H4O2 theoretically required for Ci9H22N20.C2H402= 0.0120 gm. 
QUININE. 
A M/50 quinine solution was prepared by dissolving 3.24 gm. of 
the pure anhydrous alkaloid in N/2 HCl (or N/2 acetic acid) and 
using the same acid to make up the total volume to 500 cc. The 
results obtained with these solutions are given in Tables VIII, IX, 
and X. 
Table VIII. 
Effect of the temperature of the water hath {90-95 C.) on the stability of freshly-formed 
quinine hydrochloride. 
Time re- 
mained on 
water bath 
after com- 
plete evap- 
oration of 
liquid. 
M/50 qui- 
nine taken. 
N/10 
NaOH 
required. 
N/10 
AgNOa 
required. 
Amount of 
HCl found. 
Minutes. 
cc. 
cc. 
cc. 
Gram. 
30 
10 
4. 10 
4. 08 
0. 0150 
60 
10 
,4. 03 
4.00 
.0147 
90 
10 
4.05 
4.00 
.0148 
120 
10 
4. 00 
3. 96 
.0146 
150 
10 
3. 95 
3. 96 
.0144 
180 
10 
4. 02 
4. 00 
.0147 
210 
10 
4. 00 
3. 98 
.0146 
240 
10 
3. 98 
3. 94 
.0145 
270 
10 
4. 00 
3. 98 
.0146 
300 
10 
3. 95 
4. 00 
.0144 
330 
10 
4. 00 
3. 98 
.0146 
360 
10 
3. 98 
3. 96 
.0145 
Amount of HCl theoretically required for C2oH24N2022HCl=0.014C. 
