/ 
20 
molecule of HCl, (C20H24X2O2.HCI), is given the name of a normal salt,® 
Avliile the combination of one molecule of quinine with one molecule 
of sulphuric acid (C20H24X2O2.H2SO4) is called an acid salt ^ and 
that of two molecules of quinine to one of sulphuric acid (0201124X202)2. 
H2SO4, is given the analogous name ^ (qiiinine sulphate) of the corre- 
sponding strychnine salt/ strychnine sulphate, (0211122X202)2.112804. 
In the light, however, of the results here recorded we can hardly 
look upon quinuie, for example, as a monacid alkaloid, certahily 
not as having no greater combining power with acids than strych- 
nine. For we here see that under the identical conditions (see 
Table XI) under which strychnine yields a stable combination 
(O21H22X2O2.HOI) of one molecule of strychnine to one molecule of 
HCl, one molecule of quinme (see Table ATII) requires two molecules 
of HCl to form a stable combination (C 2 oH 24 X 202 . 2 HCl). And not 
only is this chfference seen in the case of hydrocldoric acid, but 
the same difference in then combining power with acids is shovm 
also m the case of acetic acid. In the latter case, although it would 
seem at fu’st (Table X, ISO to 330 mhiutes) as showing that C|uinine 
is a monacid alkaloid since what appears as the comparatively stable 
product imder these cucumstances contains only one molecule of the 
monobasic acid (acetic acid) to one molecule of the qimiine, yet 
this very fact may be used in illustrating the difference between the 
acid combining powers of quinme and strychnine and as pointmg 
to quinine being a diacid alkaloid. For when we examme the cor- 
responding comparatively stable product of strychnine imder the 
same conditions (Table XIII, 180 to 330 mhiutes), we see that 
the difference of one molecule of the monobasic acid still holds, 
smce the stable stryclmme product under the same conditions stih 
has one molecule of the monobasic acid less than the corresponding 
quinine combination. In other words, we see that the same ‘procedure 
(Table XI) which yields what is conceded to be the normal hydro- 
chloride of stryclmme (C21H22X2O2.HCI) gives in the case of quinine 
(Table YIII) a salt of the alkaloid (C20H24X2O2.2HCI) having two mole- 
cules of the HCl to one of the alkaloid; and similarly, the same pro- 
cedure which yields in the case of strychnine (Table XIII, ISO to 330 
minutes) what must be conceded to be a basic product (since it is 
practically the pure alkaloid) yields in the case of qiiinine (Table X, 
180-330 minutes) a comparatively stable product whose composition 
corresponds closely to that of one molecule of the monobasic acid 
and one of the alkaloid (C20H24X2O2.C2H4O2). Therefore it would 
seem more in harmony with the results here presented if we regarded 
the salts of quinine, for example, in which the latter acts as a diacid 
cibid., p. 377. 
^ Ibid., p. 427. 
®U. S. Pharmacopoeia (1905), p. 376. 
& Ibid., p. 374. 
