SYNOPSIS AND TABLE OF CONTEXTS. 
Page. 
Preface 7 
Importance of the active principle of the adrenal gland. Variation in the 
activity of the commercial preparations. Importance of pharmacological 
assaying of adrenalin-like drugs. 
A. Historical 8 
Re^iew and discussion of the earlier methods. Development of the idea 
that the toxic substance of the adrenals is a distinct compound .capable of 
isolation. Separation of adrenalin in the pure form. Synthesis of the 
racemic form. Splitting of the racemic compound into its components. 
Pharmacological acti^^ty of these new products. 
B. Experimental 23 
1. Blood-pressure experiments 25 
a. Natural l-adrenalin and synthetic dl-adrenalin hydrochloride 26 
The pure adrenalin base used for a standard. Anesthesia best 
suited for such work. Nature of the syringe used in making 
the injections. Optical activity of adrenalin used. Compari- 
son of rises of blood pressures after Ic.c. injections of 1:100,000, 
1:80,000, 1:60,000, 1:50,000, 1:40,000, 1:30,000, and 1:20,000 
solutions. Ratio of relative acti\dty of these two substances. 
6. Arterenol hydrochloride, Ortho-dioxy-phenyl-ethanolamin (Arterenol) 
and natural l-adrenalin 31 
Composition and properties. 
Comparison of rises of blood pressure from 1 c. c. injections of 
1:100,000, 1:80,000, 1:60,000, and 1:50,000 solutions. Rela- 
tive pharmacological acti\dty of arterenol and l-adrenalin. 
c. Eomorenon hydrochloride, Ethyl-amino-dioxy-acetophenonand natural 
l-adrenalin 33 
Composition, properties. 
Comparison of rises of blood pressure from 1 c. c. injections 
1 : 100,000, 1 : 90,000, 1 : 60,000, 1 : 50,000, 1 : 40,000, 
1 : 30,000, and 1 : 20,000 solutions. 
Relative pharmacological acti\dty of homorenon and adrenalin. 
2. Toxicity experiments with white mice 34 
a. Natural l-adrenalin 36 
Technique of injections. 
Symptoms of intoxication. Reaction of various organs, secre- 
tion of saliva, opaquing of eye, erection, hemiplegia, sudden 
death. 
Subcutaneous injections varying from 0.0005 to 0.035 mg. of 
base per gram mouse. Lethal dose. 
( 5 ) 
