26 
by Meister, Luscius, and Briining is said to be a methyl-amino-alcohol 
or, more specifically, ortho-dioxy-phenyl-ethanor-methyl- amino-hydro- 
chloride represented by the formula 
It is a fine, granular, almost white, crystalline powder, easily 
soluble in water or normal saline. The solution decomposes much 
more readily than does a similar solution of the natural 1-adrenalin. 
It turns cherry-red, later brownish, and finally deposits a brown 
precipitate, whereupon the solution loses its characteristic color and 
likewise its physiological activity. It is optically inactive and 
possesses the chemical properties generally attributed to it. 
The data of Table I show distinctly that the natural 1-adrenalin 
is more active than the synthetic dl- since equal volumes of 1 : 100,000 
of the two solutions result in rises of blood pressure, which with few 
exceptions are greater for the natural product than for the synthetic. 
Although this table shows only a few results with 1 : 100,000 solutions, 
a great number of similar injections were made with solutions of 
them, maintaining the ratio 1 1 ; 1 dl, but varying in concentration from 
1 : 5,000 to 1 : 200,000, with the result that the natural base nearly 
always caused the greatest rise of blood pressure. So that other sets 
might be chosen to illustrate the same point as does Table I. If 
instead of the effect of the equal volume of solution of like concentra- 
tion, a comparison is made of the equal volume of solution with 
twice as much of the synthetic dl- substance as of the natural 1-, the 
rise of blood pressure from the latter is nearly always less than that 
resulting from the synthetic dl-, as Table II will show. This table 
serves to illustrate results with solutions of higher or lower concen- 
tration with the ratio 1 1 : 2 dl maintained. It is thus evident that 
with the ratio 1 : 1 the natural 1- is too strong to cause like rises of 
blood pressure, with the ratio 1 : 2 the natural 1- is too weak, and that 
the right ratio lies between these two. With a gradual increase of 
the concentration of the weaker or a decrease of the stronger a ratio 
was found that yielded the greatest number of like rises of blood 
pressure, which is 2 1: 3 dl. Tables III and V, respectivel}q show that 
a 1 : 60,000 solution of natural 1- is the equivalent of a 1 : 40,000 solu- 
tion of synthetic dl-adrenalm. Table IV shows that like rises of 
OH 
