27 
blood pressure may be obtained with equal volumes of 1 : 30,000 and 
1 : 20,000 solutions of natural 1- and synthetic dl-adrenalin, respectively. 
Table VI illustrates the same thing for cats. 
It is also true that isolated cases might be chosen to show that both 
Biberfeld and Cushny were correct, the former maintaining that 
these two products are equal in activity, the latter contending that 
the s}mthetic dl-product has only one-half the activity of the natural 
base. For in a large number of experiments one may occasionally 
obtain equal rises of blood pressure when comparing 1:50,000 of 
synthetic dl- with 1: 100,000 natural 1-adrenalin or when comparing 
solutions of equivalent concentrations. But there is no such agree- 
ment after successive sets of readings, as indicated in the accom- 
panying tables that have a ratio of concentration 2:3, instead of 1:1 
according to Biberfeld, or 1:2 according to Cushny. Cuslmy is, 
however, more nearly correct than Biberfeld, and his experimental 
data, though inadequate, carries greater weight than any hitherto 
published. Finally, my results indicate that the ratio of activity of 
the natural 1-base and the synthetic dl-product are to each other as 
2:3. These results are in accordance with my first determinations, 
made before the publication of Cushny’s first paper, and I am inclined 
to think them more nearly correct than his, which made the ratio 1:2. 
Table I. — The relative activity of natural l-adrenalin base and synthetic dl-adrenalin 
hydrochloride determined by blood 'pressure. 
Blood-pressure experiment No. 16, January 11, 1909. 
Dog, 7,660 gm. weight, subcutaneous injection of 76.6 mg. of morphine sulphate, ether anesthesia, small 
doses of curare from time to time. Both vagi cut. Artificial respiration of warmed air. Solutions injected 
into femoral veins. Five milligrams of adrenalin base dissolved in 5 c. c. Ringer 11.50 a. m. Six milli' 
grams synthetic dl-adrenalin hydrochloride crystals dissolved in 5 c. c. Ringer solution 11.55 a. m. 
Injec- 
tion. 
Base. 
Ringer. 
Time 
of 
injec- 
tion. 
Blood 
pres- 
sure 
before. 
Blood 
pres- 
sure 
after. 
Rise 
of 
blood 
pres- 
sure. 
C.c. 
Gram. 
C. c. 
P. m. 
M.m. 
M. m. 
M.m. 
Natural l-adrenalin base 
1 
1 
100,000 
1.22 
104 
171 
67 
Synthetic dl-adrenalin 
1 
1 
100,000 
1.24 
104 
155 
51 
Natural l-adrenalin 
1 
1 
100,000 
1.36 
106 
170 
64 
Synthetic dl-adrenalin 
1 
1 
100,000 
1.33 
105 
162 
57 
Natmal l-adrenalin 
1 
1 
100,000 
1.52 
97 
156 
59 
Synthetic dl-adrenalin 
1 
1 
100,000 
1.56 
93 
134 
41 
Natural l-adrenalin 
1 
1 
100,000 
2.26 
106 
160 
54 
Synthetic dl-adrenalin 
1 
1 
100,000 
2.28 
106 
152 
46 
Natural l-adrenalin 
1 
1 
100,000 
2.34 
104 
147 
43 
Synthetic dl-adrenalin 
1 
1 
100,000 
2. 31 
104 
143 
39 
Natural l-adrenalin 
1 
1 
100,000 
2.40 
104 
140 
36 
Synthetic dl-adrenalin 
1 
1 
100,000 
2. 38 
105 
134 
29 
