31 
THE RELATIVE ACTIVITY OF ORTHO-DIOXY-PHENYL-ETHANOL-AMIN 
(ARTERENOL) AND NATURAL L-ADRENALIN DETERMINED BY BLOOD 
PRESSURE. 
Another synthetic product of interest is the reduction product of 
ainino-aceto-pyro-catechin, dioxy-phenyl-ethanol-amin. The chloride 
is known commercially as arterenol hydrocholride, the formula of 
which is given as — 
OH 
H-c/ \c-OII 
H-C 
I 
/C-H 
H 
I r 
C^-CHyNH^HCl 
I 
QH 
It is a fine, granular, odorless, crystalline powder, easily soluble 
in water or normal saline. The deterioration of this product is not 
very evident, since there does not accompany it distinct coloration 
so easily noticed in adrenalin solutions. Just how rapid this process 
of deterioration is has not been determined, but it certainly is an 
important factor in determining the relative value of the substance. 
One solution received for purposes of testing was found to have an 
activity comparable to that of our natural 1-adrenalin. So surprised 
was I to note this that the balance of the sample was preserved for a 
subsequent testing, but a few days later this preparation had dete- 
riorated and a fresh solution had to be made. It can readily be seen 
that to the physician the commercial 1:1,000 solution may prove 
very disappointing if kept for subsequent use after once the original 
package has been opened. The fresh solution, however, has a 
remarkable vaso-constrictor action, and if it were more certain in 
yielding quantitative results throughout entire experiments, it would 
be a worthy rival of natural 1-adrenalin itself. In the early parts of 
long experiments fairly constant results may be obtained with small 
doses, but in the latter parts, or after larger doses (1 c. c. of 1 : 60,000 
or over), irregularities seemed to appear the exact meaning of which 
must be determined later. As a matter of fact, the following tables 
represent results taken from the beginning of experiments only. 
Table VIII is interesting, since it shows that a 1 c. c. injection of 
adrenalin or arterenol in 1:100,000 solutions causes a like rise of 
blood pressure (27-28 m. m.) and for 1 c. c. injections of a 1:50,000 
solution (38 m. m.). A 1:50,000 solution of arterenol, however, 
is uniformly more active than a 1: 100,000 solution of natural 1-base. 
Finally, consistent results are obtained by comparing the two sub- 
stances each in a concentration of 1 : 80,000 or in one of 1 : 60,000. 
