32 
Table VII . — Physiological activity of arterenol hydrochloride compared with that of 
l-natural adrenalin base. 
Blood pressure experiment No. 21, March 22, 1909. 
Female bull terrier, weight 10.4 kilograms; 10.20 a. m. subcutaneous injection of 100 milligrams morphine 
sulphate. Ether anesthesia; small intravenous injections of curare from time to time. Both vagi tied off. 
Artificial respiration with warmed air. Solutions injected into saphenous veins. 5 milligrams specially 
pure natural 1-adrenalin base dissolved (10.35 a. m.) in 5 c. c. of Ringer solution acidulated with calculated 
amount of HCl. Six milligrams arterenol hydrochloride dissolved in 5 c. c. Ringer solution 11.50 a. m. 
These two solutions were then diluted as if they were the equivalents of a 1: 1,000 solution of the base — that 
is, 1 c. c. of either one of these stock solutions diluted to 10 c. c. gave a 1:10,000 solution (base). 
Injec- 
tion. 
Base. 
Ringer. 
Time of 
injec- 
tion. 
Blood 
pres- 
sure 
before. 
Blood 
pres- 
sure 
after. 
Rise of 
blood 
pres- 
sure. 
C. c. 
Gram. 
C.c. 
P. TO. 
M. m. 
M. m. 
M. TO. 
Natural 1-adrenalin base 
1 
1 
100,000 
12. 05 
127 
182 
55 
Arterenol hydrochloride 
1 
1 
100,000 
12. 09 
126 
182 
56 
Natural 1-adrenalin base 
1 
1 
100,000 
12. 14 
127 
184 
57 
Arterenol hydrochloride 
1 
1 
100,000 
12. 18 
124 
179 
55 
Curare 
12. 21 
Natural 1-adrenalin base 
1 
1 
1 
100,000 
12.28 
130 
193 
63 
Arterenol hydrochloride 
1 1 
i 1 
100,000 
12. 31 
121 
184 
63 
Arterenol hydrochloride 
1 
1 
100,000 
1.08 
131 
152 
21 
Natural 1-adrenalin base 
1 
1 
100,000 
1.12 
131 
150 
19 
Arterenol hydrochloride 
1 
1 
100,000 
1.16 
134 
156 
22 
Natural 1-adrenalin base 
1 
1 
100,000 
1.20 
134 
155 
21 
Arterenol hydrochloride 
' 1 
1 
100,000 
1.28 
132 
154 
22 
Curare 
i 
1 2 
1.44 
Arterenol hydrochloride 
1 
1 
100,000 
2. 47 
142 
185 
43 
Natural 1-adrenalin base 
1 
1 
100,000 
2. 50 
151 
195 
44 
Table VIII. (See legend to Table V.) 
Injec- 
tion. 
1 
Base. 
Ringer. 
Time of 
injec- 
tion. 
Blood 
pres- 
sure 
before. 
Blood 
pres- 
sure 
after. 
Rise of 
blood 
pres- 
sure. 
C. c. 
Gram. 
C. c. 
P. m. 
M. TO. 
M. TO. 
M. TO. 
Natural 1-adrenalin base 
1 
1 
80,000 
6.16 
157 
187 
30 
Arterenol hydrochloride 
1 
1 
80,000 
6.20 
153 
184 
31 
Natural 1-adrenalin base 
1 
1 
100,000 
7. 24 
123 
150 
27 
Arterenol hydrochloride 
1 
1 
50,000 
7.26 
124 
162 
38 
Natural 1-adrenalin base 
1 
1 
100,000 
7.30 
126 
154 
28 
Arterenol hydrochloride 
1 
1 
50,000 
7.35 
126 
164 
38 
Arterenol hydrochloride 
1 
1 
60,000 
7.39 
124 
152 
28 
Natural 1-adrenaIin base 
1 
1 
60,000 
7. 42 
128 
155 
27 
