33 
THE RELATIVE ACTIVITY OF ETHYL-AMINO-ACETO-CATECHOL AND NAT- 
URAL L-ADRENALIN AS DETERMINED BY BLOOD PRESSURE. 
A substance known commercially as liomorenon hydrochloride 
was the last one tested. This is the hydrochloride of ethyl-amino- 
aceto-catechol represented b}" the formula: 
OH 
C 
/ \ 
H-C C-OH 
I I 
H-C C-H 
COCHyNH(C2H5)-HCl 
It is a white powder composed of fine crystalline needles, easily 
soluble in normal saline, and, so far as I have been able to deter- 
mine, keeps much better than any of the products already men- 
tioned. Its optical activity is nil. As a vaso-constrictor it is 
inferior to all of the other substances tested, as illustrated in Tables 
IX and X. A 1 c. c. injection of a 1:160,000 solution of natural 
1-adrenalin causes a rise of blood pressure which with a like volume 
of liomorenon is equaled onl}^ by a 1 : 2,000 solution. It is found 
that a 1 c. c. injection of a 1 : 80,000 solution of adrenalin base causes 
the same rise of blood pressure as a 1 c. c. injection of a 1:1,000 
solution of liomorenon. So that by the blood-pressure method, 
natural 1-adrenalin base is eighty times as active as liomorenon base, 
the base being calculated from the foregoing formula. 
Table IX. — Physiological activity of homorenon hydrochloride compared with that of 
l-natural adrenalin base. 
Blood-pressure experiment No. 20. March 16, 1909. 
Female fox terrier, weight 6.S kilograms. 10.15 a. m. subcutaneous injection of 68 mg. of morphine sul- 
phate. Ether anesthesia, small intravenous injections of curare from time to time. Both vagi tied off. 
Artificial respiration of warmed air. Solutions injected into saphenous veins. 
Five milligrams specially pure adrenalin 1-base dissolved 10.23 a. m. in 5 c. c. of Ringer solution, acidu- 
lated with the calculated amount of HCl. 
Six milligrams arterenol hydrochloride dissolved 6 p. m. in 5 c. c. Ringer solution. 
118.6 mg. homorenon h 3 Mroehloride dissolved 11.30 a. m. in 10 c. c. of Ringer solution. These solutions 
were then diluted as if they were the equivalents of a 1 : 1,000 solution of adrenalin base. 
Injec- 
tion. 
Base. 
Ringer. 
Time of i 
injec- 
tion. 
Blood 
pres- 
sure 
before. 
Blood 
pres- 
sure 
after. 
Rise of 
blood 
pres- 
sure. 
Natural 1-adrenalin base 
C. c. 
1 
Gram. 
1 
C. c. 
160,000 
2,000 
P. m. 
3.49 
M. m. 
180 
M. m. 
204 
M. TO. 
24 
Homorenon hvdrochloride 
1 
1 
3. 51 
178 
202 
24 
Natural 1-adrenalin base 
1 
1 
160,000 
160,000 
2,000 
3. 55 
177 
202 
25 
Natural 1-adrenaIin base 
1 
1 
4. 6 
160 
186 
26 
Homorenon hydrochloride 
1 
1 
4.9 
150 
175 
25 
177— Bull. 55—09 3 
