34 
Table IX . — Physiological activity of homorenon hydrochloride compared v:ith that of 
l-natural adrenalin base — Continued. 
1 
Injec- 
tion. 
I 
Base. , 
Ringer. 
Time of 
injec- 
tion. 
Blood ' 
pres- i 
sure ■ 
before. | 
Blood 
pres- 
sure 
after. 
Rise of 
blood 
pres- 
sure. 
C. c. 
1 
Gram. 
C. c. 1 
P. m. 
M. TO. ' 
M. TO. 
M. TO. 
Natural 1-adrenalin base 
1 
1 
160,000 ! 
4.31 
156 : 
178 
22 
Homorenon hvdrocbloride 
1 . 
1 
2,000 
4. 36 
154 
177 ! 
23 
Natural 1-adrenalin base ' 
! 1 
1 
160,000 
5. 15 
172 ! 
186 : 
21 
Homorenon hvdrocbloride 
! 1 
1 
2,000 
5.19 
173 
195 
22 
Natural 1-adrenalin base 
! 1 
1 
160,000 
5. 22 
172 ■ 
194 
22 
Homorenon hvdrocbloride 
1 
1 
2,000 
5. 25 
169 
191 
22 
Homorenon hvdrocbloride 
’ 1 
1 
2,000 
5. 32 
155 
176 
21 
Table X. (See legend to VI.) 
Injec- 
tion. 
Base. 1 
Ringer. 
Time of ; 
injec- 1 
tion. ; 
Blood 
pres- 
sure 
before. 
Blood 
pres- 
sure 
after. 
Rise of 
blood 
pres- 
sure. 
C. c. 
Gram. 
C. c. 
P. TO. 
Jf.TO. i 
Jl.m. 
Af. TO. 
Natural 1-adrenalin base 
1 
1 
80,000 
1. 57 
138 i 
180 
42 
Homorenon hvdrocbloride 
1 
1 
1,000 
2.1 
138 
1 180 
42 
Natural 1-adrenalin base 
1 
1 
80,000 
2.28 
158 
I 208 
50 
Homorenon hvdrocbloride 
1 
1 
1,000 
2.33 
156 
' 205 
49 
Natural 1-adrenalin base 
1 
1 
80,000 
2.39 
166 
215 
49 
Homorenon hvdrocbloride 
1 
1 
1,000 
2. 56 
164 
200 
36 
Natural adrenalin base 
1 
1 
80,000 
3.02 
162 
198 
36 
Homorenon hvdrocbloride 
1 
1 
1,000 
3. 04 
156 
193 
37 
Natural adrenalin base 
1 
1 
80,000 
3.09 
160 
198 
38 
Natural adrenalin base 
1 
1 
80,000 
3.39 
174 
i 228 
54 
Homorenon hvdrocbloride 
1 
1 
1,000 
170 
i 223 
1 • 
53 
THE RELATIVE TOXICITY OF ORTHO-DIOXY-PHENYL-ETHANOL-METHYL- 
AMIN (NATURAL L- AND SYNTHETIC DL-ADRENALIN), OF ORTHO-DIOXY- 
PHENYL-ETHANOL-AMIN (“ARTERENOL”), AND ETHYL-AMINO-DIOXY- 
ACETO-PHENON (“HOMORENON”) AS DETERMINED UPON MICE. 
It is conceivable that coefficients of physiological activity of a 
series of closely related compounds, when determined by vasomotor 
effects, may be so arranged as to express one ratio, whereas those 
determined by toxic effects when similarly arranged may express 
a very different one. That is, a coefficient determined by the 
blood-pressure method may be relatively small when compared 
with that determined by the dose necessary to kill, say, more 
than 50 per cent of the animals injected. It would seem that a 
comparison of such coefficients determined in various ways might 
throw additional light on the relative safety and effectiveness of 
adrenalin-like bodies. But scarcely anything has been published from 
which can be derived the coefficients needed in making the above- 
