36 
12.26, lies flat, restless from time to time, hind leg stretched out, but Tvhen touched 
is jerked away. 
12.30, forced breathing. 
12.33, abundant salivation, leg still sensitive, but control of hip muscle imperfect. 
12.37, lies flat; does not move when tail is pinched; feet and leg still sensitive, but 
reflex not so rapid as before. 
1.34, opaque disc in center of left eye. 
2.35, opaque disc of left eye much larger, opaque disc in right eye also. 
March 16, 8.15 a. m. Both eyes cleared up, mouse prostrated. 
March 17, 9 a. m. Mouse prostrated, eye clear, breathing shallow and slow. 
12.20, found dead. 
The saliva may or may not flow abundantly, but when it does the 
amount is so great as to drop from the lower jaw. In the males 
erection may follow and even be accompanied by semination. Should 
the dose be lethal the earlier stages are passed through quickly; in 
general the animal becomes very sluggish, largely on account of 
constriction of the blood vessels, causing anaemia not only of the 
muscles, but also of the cord and brain. Sometimes animals die 
very suddenly from doses that seem hardly to affect other individ- 
uals. I am inclined to think that in such cases some of the drug 
enters a vein. Otherwise there does not occur any explanation, 
unless it be due to heart failure, such as indeed has been noted in 
apparently vigorous human beings under the influence of great fear 
or excitement. lYhen spasms result, the animal usually dies in 
one to two minutes; only one out of over four hundred recovered, 
and this one died at the end of four or five days. IVhen once the 
lethal dose is exceeded death becomes more violent, accompanied 
by spasms of very short duration. 
TOXICITY OF XATUEAL L-ADEEXALIX. 
Judging from the remarkable activity of the natural 1-adrenalin in 
causing vaso-constriction, it was presumed that the lethal subcuta- 
neous dose would be small. The experimental data of Table I justi- 
fies this presumption, for 0.008 mg. per gram mouse is usually fatal. 
Certain mice may die from doses as small as 0.004 mg. per gram, but 
this is the exception, whereas others may survive as much as 0.017 
mg. per gram, which is likewise unusual. Perhaps a greater num- 
ber of experiments might reveal certain cases of even greater resist- 
ance, but in spite of these exceptions, as seen in Table XI, it may be 
said that 0.008 is the lethal dose for the a^mrage mouse. 
