39 
TOXICITY OF SYNTHETIC DL- ADRENALIN. 
If instead of natural 1-adrenalin synthetic dl-adrenalin hydrochloride 
be used the symptoms of toxicity are practically the same as those 
described for adrenalin. There is, however, greater irregularity in 
the results. In exceptional cases 0.006 to 0.008 mg. per gram 
mouse may cause death. (Table XII.) By increasing the size of 
the initial dose the number of deaths likewise becomes larger, so that 
injections of 0.012 mg. may result in a death rate even as high as 
does one of 0.020 mg. per gram body weight. The lethal dose, 
therefore, may be said to be from 0.012 to 0.016 mg. per gram. 
This would make the natural product 1.5 to 2 times as toxic as the 
synthetic. It is interesting to observe that the toxicity of the two 
substances is in direct proportion to their vaso-constrictor action as 
measured by the blood-pressure method. 
Table XII. — Toxicity of synthetic dl-adrenalin hydrochloride. 
Number of 
Mg. base 
Body 
Injected. 
i 
Died. 
mouse. o 
per gm.6 
weight. 
Total. 
Time. 
102 
0. 002 
Grams. 
15. 48 1 
Mg. 
0. 030 
C.c. 
0. 03 
• 
Dec. 9, 9.45 a. m 
142 
0.002 
26. 57 
0. 053 
0. 05 
Dec. 10, 3.43 p. m 
147 
0. 002 
! 25. 27 
0. 05 
0. 05 
Dec. 10, 3.56 p. m 
103 
0. 004 
14. 44 
0.06 
0. 06 
Dec. 9, 9.48 a. m 
143 
0. 004 
23.24 
0. 092 
0. 09 
Dec. 10, 3.45 p. m 
148., 
0. 004 
17.43 
0. 069 
0. 07 
Dec. 10, 3.58 p. m 
104 
0. 006 
15. 22 
0.091 
0.09 
Dec. 9, 9.51 a. m 
144 
0. 006 
23.50 
0. 141 
0. 14 
Dec. 10, 3.48 p. m 
149 
0. 006 
23. 00 
0. 138 
0.14 
Dec. 10, 3.59 p. m 
343 
0. 006 
13. 56 
0. 081 
0. 08 
Mar. 15, 3.10 p. m 
Mar. 15, 3.32 p. m. 
344 
0. 006 
i 11.77 
0. 070 
0. 07 
Mar. 15, 3.11 p. m 
345 
^ 0. 006 
1 
1 12. 97 
0. 077 
0. 07 
Mar. 15, 3.12 p. m 
346 
0. 006 
13. 34 
0.080 
0. 08 
Mar. 15, 3.14 p. m 
347 
0. 006 
14. 72 
0. 088 
0. 08 
Mar. 15, 3.16 p. m 
105 
0. 008 
17. 24 
0. 138 
0. 14 
Dec. 9, 9.53 a. m 
Dec. 10, 12 m. 
145 
0. 008 
24.21 
0. 194 
0. 19 
Dec. 10, 3.50 p. m * 
150 
0. 008 
24.24 
0. 194 
0. 19 
Dec. 10, 4.01 p. m 
348 
0. 008 
0. 008 
20. 46 
0. 163 
0. 16 
Mar. 15, 3.18 p. m 
349 
16. 15 
0. 130 
0. 13 
i 
Mar. 15, 3.20 p. m 
Mar. 15, 5.30 p. m. (F.). 
350 
0. 008 
15.39 
0. 123 
0. 12 
Mar. 15, 3.22 p. m 
351 
0. 008 
13. 84 
0. 110 
0. 11 
Mar. 15, 3.24 p. m ' 
106 
0. 010 
15. 87 
0. 159 
0. 16 
Dec. 9, 9.56 a. m 
Dec. 10, 12.15 a. m. (W.). 
146 
0. 010 
22. 46 
0. 225 
0. 22 
Dec. 10, 3.53 p. m 
151 
0. 010 
19. 37 
0. 193 
0. 19 
Dec. 10, 4.03 p. m 
353 
0. 010 
0. 010 
15. 45 
11, 80 
0. 154 
0. 15 
Mar. 15, 3.34 p. m ! 
354... . 
0. 118 
0. 12 
Mar. 15, 3.35 p. m i 
355 
0. 010 
i 17.38 
0. 173 
0.17 
Mar. 15, 3.37 p. m j 
Mar. 16, 8 a. m. (F.). 
a Mice not marked “ W ” or “ F ” were observed by the author to die at the time noted. 
b These figures are only approximate. The actual dose is in column “Total milligrams injected." 
W. Time noted by watchman. 
F. Foiond dead at time noted. 
