40 
Table XII. — Toxicity of synthetic dl-adrenalin hydrochloride — Continued. 
Number of 
Mg. base 
Body 
Injected. 
Died. 
mouse. 
per gm. 
weight. 
Total. 
Time. 
356 
0. 010 
Grams. 
12. 26 
Mg. 
0. 122 
C. c. 
0. 12 
Mar. 15, 3.39 p. m 
357 
0.010 
18. 47 
0. 184 
0.18 
Mar. 15, 3.40 p. m 
Mar. 17, 1.15 a. m. 
161 
0. 012 
18.09 
0.217 
0. 22 
Jan. 4, 3.25 p. m 
164 
0. 012 
15. 11 
0. 181 
0. 18 
Jan. 4, 3.35 p. m 
Jan. 6, 2.30 p. m. 
167 
0. 012 
15. 18 
0. 182 
0. 18 
Jan. 4, 3.40 p. m 
Jan. 5, 12.15 a. m. (W.). 
188 
0. 012 
14. 55 
0. 174 
0. 17 
Jan. 8, 11.29 a. m 
191 
0. 012 
16. 20 
0. 194 
0. 19 
Jan. 8, 11.44 a. m 
Jan. 9, 1.30 a. m. (W.). 
194 i 
0. 012 
15. 15 
0. 181 
0. 18 
Jan. 8, 11.52 a. m 
Jan. 10, 10.30 a. m. (W.). 
358 
0. 012 
18. 00 
0. 180 
0. 18 
Mar. 15, 3.42 p. m 
359 
0. 012 
13. 62 
0. 136 
0. 13 
Mar. 15, 3.44 p. m 
360 
0. 012 
13.49 
0. 135 
0. 13 
Mar. 15, 3.46 p. m 
361 
0.012 
15. 80 
0. 158 
0. 15 
Mar. 15, 3.47 p. m 
362 
0. 012 
20. 24 
0. 202 
0. 20 
Mar. 15, 3.48 p. m 
162 
0. 016 
19.91 
0. 319 
0. 32 
Jan. 4, 3.28 p. m 
Jan. 5, 1.30 a. m. (W.). 
165 
0. 016 
15. 92 
0. 255 
0. 25 
Jan. 4, 3.36 p. m 
Jan. 6, 10.05 a. m. 
168 
0. 016 
15. 35 
0. 246 
0. 25 
Jan. 4, 3.44 p. m 
189 
0. 016 
14. 35 
0. 230 
0. 23 
Jan. 8, 11.40 a. m 
Jan. 10, 10.30 a. m. (W.). 
192 
0. 016 
21.54 
0. 345 
0. 34 
Jan. 8, 11.48 a. m 
Jan. 8, 4.50 p. m. (F.). 
195 
0. 016 
14.08 
0. 225 
0. 23 
Jan. 8, 12.05, p. m 
Jan. 10, 10.30 a. m. (W.). 
163 
0. 020 
21. 37 
0. 427 
0. 43 
Jan. 4, 3.32 p. m 
166 
0. 020 
17. 85 
0. 357 
0. 36 
Jan. 4, 3.38 p. m 
Jan. 5, 12.15 a. m. (W.). 
169 
0. 020 
15. 54 
0. 311 
0. 31 
Jan. 4, 3.47 p. m 
190 
0. 020 
17. 53 
0. 350 
0. 35 
Jan. 8, 11.42 a. m 
Jan. 8, 4.50 p. m. (F.). 
193 
0. 020 
19. 30 
0. 386 
0. 39 
Jan. 8, 11.50 a. m 
Jan. 9, 2.30 a. m. (W.). 
196 
0. 020 
12. 54 
0. 250 
0. 25 
Jan. 8, 12.07 p. m 
W. Time noted by watchman, 
F. Found dead at time noted. 
Note. — Concentration of the solutions made from synthetic dl-adrenalin hydrochloride crystals and th 
time of mixing them are as follows: 
Nos. 102 to 106, inclusive, G mg. crystals in 5 c. c. Ringer solution about 9 a. m. December 9, 1908. 
Nos. 142 to 151, inclusive, 6 mg. crystals dissolved in 5 c. c. of Ringer solution just before using. 
Nos. 161 to 169, inclusive, 6 mg. crystals dissolved in 5 c. c. of Ringer solution aboiat 3 p. m. January 4, 1909. 
TOXICITY OF ARTERENOL HYDROCHLORIDE. 
Arterenol (see Table XIII) differs from natural 1- and synthetic dl- 
products in two essentials; (1) it is far less toxic, and (2) it is, as said 
before, more variable in its action. If the animal can survive the 
first tremendous strain upon the organism, it has greater chances of 
recovery from arterenol than from doses of adrenalin causing a cor- 
responding degree of prostration. If the animal is again injected 
after recovery from sublethal doses, the resulting prostration is as a 
rule correspondingly less severe, and doses that are usually lethal no 
longer proved to be so. This is illustrated by mice in groups (a) and (b) 
(Table XIII) . In the one case 0.040 mg. and in the other 0.080 mg. per 
gram mouse is with one exception in each group successfully resisted. 
Whether or not this is a case of acquired tolerance or whether it is a 
