44 
injected more than once and some of the solutions were not used immediately, the 
following data is inserted to show this : 
Mice Nos. 67 to 70, inclusive, 5 mg. arterenol hydrochloride crystals dissolved in 
5 c. c. Ringer solution between 9 and 11 a. m. December 4, 1908. 
Nos. 67, 68, 69, and 70 were previously injected November 30 with 0.22, 0.28, 0.42, 
and 0.61 mg., respectively, of homorenon hydrochloride. 
Mice Nos. 107 to 111, inclusive, 6 mg. arterenol hydrochloride dissolved in 5 c. c. 
Ringer solution 9 a. m. December 9. 
Nos. 117 to 121, inclusive, 6 mg. arterenol hydrochloride dissolved in 5 c. c. Ringer 
solution 11.30 a. m. December 9. 
Nos. 179, 180, 181, 182, 183, 184, 185, 186, and 187, 6 mg. arterenol hydrochloride 
dissolved in 5 c. c. Ringer January 5 just before injecting; 179a, 180a, 181a, 182a, and 
183a injected with a solution made up 3 p. m. January 7, for blood-pressure experi- 
ment on January 7, whereas 184a, 185a, and 186a were injected with a solution made 
up in the same way 12.49, January 8. 
Nos. 197, 198, 199, 200, and 202, 6 mg. arterenol hydrochloride dissolved in 5 
c. c. Ringer, 12.49 p. m. January 8, 1909; 203, 204, and 205 similar solution made up 
1.50 p. m. January 8; 197b, 200b, 201b, and 205b injected with a solution containing 
12 mg. arterenol crystals dissolved in 5 c. c. Ringer, 10.57 p. m. January 16. 
Nos. 206, 207, 208, 209, 210, 211, 212, 213, and 214, 6 mg. arterenol hydrochloride 
crystals dissolved in 5 c. c. Ringer 1.30 p. m. January 9, 1909; 206a, 209a, 210a, 212a, 
and 213a, 6 mg. crystals per 5 c. c. dissolved 3.53 p. m. January 12. 
Nos. 206b, 209b, 210b, 212b, and 213b, 12 mg. arterenol HCl dissolved in 5 c. c. 
Ringer 10.57 p. m. January 16. 
Nos. 217b, 219b, and 222b, 12 mg. arterenol hydrochloride crystals dissolved in 5 c. c. 
Ringer 10.57 p. m. January 16. 
Nos. 233, 234, 235, 236, 237, 238, 239, 240, and 241, respectively, injected January 5 
with 0.17, 0.30, 0.33, 0.24, 0.30, 0.32, 0.20, 0.23, and 0.32 mg. of arterenol hydro- 
chloride and with the same drug again on January 8 with 0.32, 0.59, 0.66, 0.45, 0.59, 
0.56, 0.38, 0.41, and 0.59 mg., respectively. 
TOXICITY OF HOMORENON HYDROCHLORIDE. 
It has been shown that it requires eighty times as much homorenon 
to produce the same rise of blood pressure in the dog as is caused 
by the same amount of natural 1-adrenalin. If the relative toxicity 
of this compound as compared wdth 1-adrenalin were in direct pro- 
portion to the relative vaso-constrictor action, then the lethal dose 
of homorenon ought to be 0.640 mg. per gram mouse, and as a matter 
of fact the lethal dose is somewhere between 0.568 and 0.711 mg. 
per gram mouse. It is true that a smaller dose than this some- 
times kills and very rarely a mouse may survive as large a dose 
as 0.994 mg. per gram. But anything above 0.568 mg. so often 
kills that one is safe in saying that the lethal dose is slightly more 
than 0.568 and a little less than 0.711 mg. per gram body weight. 
According to Table XIV, then, the natural 1-adrenalin is from eighty 
to eighty-eight times as toxic as ethyl-amino-aceto-catechol, com- 
mercially known as homorenon. 
