15 
limited amount of oats ; there was a decrease in the body weight but 
a strikingly increased resistance to acetonitrile. 
The following experiments will serve to illustrate these points; 
Date. 
Weight of 
mouse. 
Remarks. 
January 18, 1905 
Grams. 
18.21 
Limited food begun. 
January 24, 1905 
17.01 
January 30, 1905 
15. 92 
February 6, 1905 
16.42 
February 13, 1905 
12.61 
February 15, 1905 
14.11 
On this morning the mouse was given full food 
February 16, 1905 
February 21, 1905 
16.93 milligrams acetonitrile (=1.2 milligram: 
per gram body weight). Survived. 
Alcohol, 5 per cent on oats. 
Alcohol increased to 10 per cent. 
February 24, 1905. . . 
14.02 
February 27, 1905 
Alcohol increased to 20 per cent. 
March 3, 1905 
13.61 
March 10, 1905 
14. 10 
Alcohol increased to 25 per cent. 
March 18, 1905 
14.05 
March 22, 1905 
Alcohol increased to 35 per cent. 
Alcohol increased to 45 per cent. 
March 29, 1905 
14.25 
April 5, 1905 
15. 32 
April 11, 1905 
April 14, 1905 
14. 85 
Alcohol increased to 60 per cent. 
4.46 milligrams acetonitrile (=0.3 milligram: 
per gram body weight). Died. 
The following control experiments were made: (a) (To the first 
injection) other mice of the same lot, which had been allowed to eat 
all that they would, succumbed to 0.6 and 0.65 milligram per gram 
body weight, while others of the series, which had been kept on the 
reduced diet, survived 0.9 and 1 milligram acetonitrile per gram body 
weight; (b) (to the second injection) mice, which had been kept on 
oats and water for the same length of time that the others had received 
alcohol, survived 0.65 and 0.6 milligram per gram. Other experi- 
ments of this series are as follows: 
Date. 
Weight of 
mouse. 
Remarks. 
February 16, 1905 
February 21, 1905 
February 27, 1905 
March 1, 1905 
Grams. 
23.16 
18.85 
18.25 
Limited food begun. 
20.08 milligrams acetonitrile (=1.1 milligrams 
per gram body weight). Survived. 
Alcohol, 5 per cent on oats. 
Alcohol increased to 10 per cent. 
Alcohol increased to 20 per cent. 
Alcohol increased to 25 per cent. 
Alcohol increased to 35 per cent. 
Alcohol increased to 45 per cent. 
March 6, 1905 
March 7, 1905 
18. 95 
March 12, 1905 
March 14, 1905 
March 16, 1905 
19. 61 
March 21, 1905 
19. 26 
March 29, 1905 
April 5, 1905 
18.92 
19.05 
April 7, 1905 
19.02 
5.71 milligrams acetonitrile (=0.3 milligrams 
per gram). Died in 2 hours. 
24417— No. 33—07 3 
