16 
Controls (a) (that is, mice which had received full food as long as the 
above one had received limited food) died from 0.65 and 0.6 milligram 
per gram mouse; controls (b) (that is, mice which had received oats 
and water as long as the above had received oats and alcohol) sur- 
vived 0.6 and 0.55 milligram. 
Another striking experiment of this character is the following: 
Date. 
Weight of 
mouse. 
Remarks. 
February 16, 1905 
Grams. 
18.15 
Limited food begun. 
February 21, 1905 
15. 25 
February 28, 1905 
13.57 
27.14 milligrams acetonitrile (=2 milligrams per 
March 3, 1905 
gram). Suryiyed. 
5 per cent alcohol on food. 
March 7, 1905 
15. 52 
March 8, 1905 
Alcohol increased to 10 per cent. 
March 12, 1905 
Alcohol increased to 20 per cent. 
March 14, 1905 
17. 85 
March 16, 1905 
Alcohol increased to 25 per cent. 
March 21, 1905 
18.27 
Alcohol increased to 35 per cent. 
March 29, 1905 
18.80 
Alcohol increased to 45 per cent. 
April 5, 1905 
April 6, 1905 
19.35 
19.31 
6.76 milligrams acetonitrile (=0.35 milligrams 
per gram). Died in 18 hours. 
Thus tliis mouse, when receiving a limited amount of food, recov- 
ered from four times the absolute amount of nitrile which caused death 
after it had been given alcohol; it recovered from nearly six times the 
relative dose (that is, in proportion to body weight). 
Two control experiments of this series are given in detail, for in 
them the mice, although receiving all the food they would eat, also 
lost some weight but did not show an increased resistance to the nitrile. 
Date. 
Weight of 
mouse. 
Remarks. 
February 16, 1905 
Grams. 
24. 82 
Full feed. 
February 24, 1905 
21. 52 
February 27, 1905 
21. 57 
14.02 milligrams acetonitrile (=0.65 milligrams 
per gram). Died in 4J hours. 
The mouse in the experiment described immediately before this one 
had recovered from 27.14 milligrams, or from nearly double the abso- 
lute amount which was fatal in this case; the relative figures (that is, 
in proportion to body weight) were 3 to 1. 
