17 
Excreted in the urine as amidoplienol or amidophenetol, which gives 
a red color with ferric chloride; also causes appearance of a reducing 
substance. 
Similar Compounds. — This is the representative of a very large num- 
ber of similar compounds known as the phenetidin series. These are 
derived from para-amidophenol by replacing the hy- 
drogen atom of the hydroxyl group and one or both of the hydrogen 
atoms of the amido (XH. 2 ) group by alkyl or acid radicals. Thus, lac- 
tophenin is formed when the lactyl group (COCH(OH)CH 3 ) is intro- 
duced into para-phenetidin instead of the acetyl (CH 3 CO) group: 
OC H 
. Sedating apolysin , citrophen , kryofin , 
malakin , sal ophen , sal iphen , phenocoll , salocoll , etc., are similar com- 
pounds. The plrvsiological action of all these substances is funda- 
mentally the same. These compounds, as well as acetphenetidin itself, 
are contained in many migraine and headache powders. Chinophenin 
and eupyrine are also phenetidin compounds. 
ACIPU3I CA3IPHOR1COI. 
Camphoric Acid. 
r 7 1 .COOH 
e s nu^ C00H 
4 * A dibasic organic acid obtained by the oxidation of camphor." 
Official under same name in the German Pharmacopoeia. 
Of the various camphoric acids known, only the dextro-rotatory is 
official. It is prepared by oxidizing camphor with nitric acid. 
Character. — Colorless, odorless crystalline plates, or a crystalline 
powder having an acid, bitter taste. Melting point, 187° C. It forms 
easily soluble salts with the alkalies. 
Solubility.— Difficultly soluble in cold water (1:125), more readily in 
boiling water (1:10); readilv soluble in alcohol; soluble in fatty oils 
(1:50). ' 
Purity.— Should not have the odor of camphor; tested by the U. S. 
Pharmacopoeia method should be free from nitric acid. 
Action. — The general symptoms produced by camphoric acid are 
similar to those caused by camphor, but the latter is much more 
powerful. Used as an antihydrotic in doses of 1 to 2 Gm. and (in 
solution) as a local astringent in the nose, throat, and bladder. As it is 
but slightly soluble in water, it has been recommended in making solu- 
tions to add 11 per cent of alcohol for each per cent of camphoric acid. 
Dose. — 44 Average dose: 1 Gm. (15 grains)." (U. S. P.) 
GuakampJiol is a combination of Guaiacol and Camphoric Acid. 
a The name sedcitin has also been used as a synonym for antipvrine, 
31207— No. 23—05 2 
