23 
Incompatibilities. — Hager's Handbuch der pharmaceutischen Praxis 
calls attention to the incompatibility of Antipyrine with a large num- 
ber of substances and the production therewith of unexpected changes; 
among these may be mentioned: 
(1) Antipyrine and nitrous acid, or substances which can evolve 
nitrous acid, as, for instance, Amylis Nitris and Spiritus /Etheris 
Nitrosi; a green color results from the formation iso-nitroso-antipyrine. 
(2) Antipyrine and Mercurous Chloride (calomel); a very poisonous 
organic mercury compound is formed in a mixture of these substances. 
(3) Antipyrine and Phenol, even in dilute aqueous solution, form an 
oily mass. 
(4) Antipyrine and Sodii Salicvlas, when rubbed together in powder, 
form a pasty mass; in solution the} r do not seem to affect each other. 
(5) Antipyrine and Betanaphthol give a moist mixture. 
(6) Antipyrine and Hydrated Chloral, rubbed together, form an oil 
which no longer gives the reactions of the components. 
(7) Tannic acid precipitates Antipyrine as a tannate. 
On the other hand, Antipyrine increases the solubility in water of 
caffeine and the quinine salts. 
Allied Compounds. — Antipyrine unites with resorcin to form reso- 
pyrin , with salicylic acid to form salt pyrin, with chloral hydrate to 
form hypnal and other compounds. Pymmidon is a dimethylamjdo 
substitution product of antipyrine. F’erripyrin is a combination of 
ferric chloride and antipyrine. Many other compounds are known. 
Antipyrine is a constituent of many “ migraine powders/' 
Dose. — “ Average dose: 0.250 Gm. = 250 milligrammes (4 grains).” 
(U. S. P.) 
Caution. — On account of the wide range of incompatibilities already 
indicated, the greatest* caution should be observed in combining anti- 
pyrine with other substances. 
AQUT. 
Waters. 
Medicated Waters. 
“The Medicated Waters, when prepared from volatile oils, are 
intended to be, as nearly as practicable, saturated solutions, which 
must be clear, and free from solid impurities.” 
This is a new title under which various methods of preparing official 
waters of volatile oils are briefly outlined. In the method especially 
recommended by the Pharmacopoeia, in a number of cases, the solu- 
tion of the volatile oils is facilitated by the use of purified talc, instead 
of by precipitated calcium phosphate, as in U. S. Pharmacopoeia, 1890. 
