Soluble in water (1:18.7) and alcohol (1:1.3), readily, in glycerin and 
acetone. It is not affected by dilute acids, but is decomposed, on 
warming with alkali hydroxides, yielding chloroform; it behaves in 
this respect like chloral hydrate, and is, hence, incompatible with 
alkalies. Chloral is formed by its decomposition in the body; the 
formamide which is formed at the same time is supposed to stimulate 
the circulation and thus counteract the depression caused by the 
chloral. 
Dose. — “ Average dose: 1 Gm. (15 grains)." (IT. S. P.) 
Caution. — Keep in amber-colored, well-stoppered bottles. It is 
easily decomposed in solution by heat; hence heat should not be used 
in preparing aqueous solutions. Avoid combination in full dose 
with other drugs of a similar physiologic action, for example, Sul- 
phonethylmethane ( trional ), Sulphonmethane (sulphonal), Hydrated 
Chloral, etc. 
Allied Compounds. — Chloral, like other aldehydes, forms many addi- 
tion products more or less comparable with chloralformamide. Thus, 
with ethyl carbamate, chloral unites to form uralium; with dextrose 
it forms chloralose / with antipyrine, hypnal / with amylene hydrate, 
dormiol , etc. 
Croton chloral (Butyl-chloral Hydras, Br. P.) is trichlorbutylalde- 
hyde hydrate (CH 3 CHC1CC1 2 CH(0H) 2 ). Other tri-chlor substitution 
products recently proposed as hypnotics are chloretone or ant-son 
(trichlorpseudobutylalcohol or acetone-chloroform) and isopral (tri- 
chlorisopropyl alcohol). 
CINNALDEHYDUM. 
Cinnamic Aldehyde. 
C 6 H 5 CH :CH.COH 
Obtained from oil of cinnamon or prepared synthetically. It is the 
chief and essential constituent of oil of cinnamon, and should be 
present to the extent of about 75 per cent by' volume in a good oil. 
Character. — A colorless liquid, having a cinnamon-like odor and a 
burning, aromatic taste. It may be used for nearly all purposes in 
place of the official oil of cinnamon. Pure symthetic Cinnamic Alde- 
hyde occurs in the market, and has, to a great extent, displaced the 
natural oil of cinnamon. 
Solubility. — Sparingly soluble in water, readily in alcohol, fixed and 
volatile oils. 
Dose. — “Average dose: 0.05 Cc. (1 minim)." (U. S. P.) 
