41 
Character. — Colorless, lustrous, odorless crystals, having a sweetish, 
then somewhat bitter, taste. Its aqueous solution has an alkaline 
reaction to litmus. 
Solubility. — Easily soluble in water (1:1.5), less so in alcohol (1:10). 
In solution it is decomposed by dilute sulphuric acid with liberation 
of formaldehyde; it is precipitated by tannic acid and mercuric chloride. 
Dose. — “Average dose: 0.250 Gm.= 250 milligrammes (4 grains).” 
(U. S. P.) 
Caution. — It should be kept in well-stoppered bottles. 
Allied Compounds. — Hexamethylene-tetramine readily forms com- 
pounds with a large number of substances; among those suggested for 
use in medicine the following may be mentioned: 
Hexamethylenamine salicylate, urotropin salicylate , or saliformin; a 
colorless, crystalline powder of nauseous, sweetish, astringent taste. 
Hexamethylenamine-ethylbromide, bromalin , or hr om.of armin' a 
colorless, crystalline powder of a sweetish saline taste. 
Hexamethylenamine-tannin, tannopin , or tannon ; a brown tasteless 
powder, nearly insoluble in water and alcohol. 
Dioxybenzol-hexamethylenamine, hetralin , contains 60 per cent of 
hexamethylenamine. 
Chinotropin and chinoformin are quinates of hexamethylenamine. 
Helmitol is a recently^ introduced compound of hexamethydenamine with 
anhy^dromethylene citric acid. Citarin (sodium anhydromethylene 
citrate) is another compound from which formaldehyde is split off in 
the organism. 
HOMATROPINT HYDROBROMIPUM. 
Homatropine Hydrobromide. 
C 16 H 21 N0 3 .HBr 
Official under the same name in the British Pharmacopoeia; as Hom- 
atropinum hydrobromicum in the German and Swiss Pharmacopoeias. 
“The hydrobromide of an alkaloid obtained by the condensation of 
tropine and mandelic acid.” 
Chemistry. — Atropine may be broken up, by the action of alkalies, 
into an alkaloid, tropine, and an aromatic acid, tropic acid. Tropine 
is a pyridine derivative having the structural formula 
CH 2 — CH CH 2 
N(CH 3 ) CHOH 
CH— CH CH 2 
Tropine forms ester-like compounds with many acids; the compounds 
with aromatic acids are called tropeins. Homatropine is one of these 
tropeins; as stated above, it is formed by the union of tropine and 
mandelic acid; the latter is phenydglycollic acid ^C 6 H 6 CH<q^q^^. 
