47 
Methylene azure is almost always present in even the best specimens 
of methylene blue. It may be detected by adding- ammonia to a 
solution of methylene blue and then shaking with ether; the methy- 
lene azure passes into the ether, which is colored red. 
OLEATA. 
Oleates. 
Three new oleates have been introduced and one (Oleatum Zinci, 
U. S. P., 1890) dropped. 
For method of preparation see the Pharmacopoeia. 
The oleate of quinine is also in the National Formulary; other 
(unofficial) oleates in the National Formulary are: oleate of aconitine, 
lead oleate, and zinc oleate (different from the U. S. P. 1890 Oleate of 
Zinc). 
OLEATUM ATROPIN.E. 
Oleate of Atropine. 
Containing 2 per cent of atropine. 
OLEATUM COCAIN.E. 
Oleate of Cocaine. 
Containing 5 per cent of cocaine. . 
OLEATUM QUININiE. 
Oleate of Quinine. 
Containing 25 per cent of quinine. 
OPIUM GRANULATUM. 
Granulated Opium. 
Opium dried at a temperature not exceeding 85° C. and reduced to 
a coarse (No. 20) powder; Opii Pulvis is prepared similarly, but it is 
reduced to a very fine powder; the Pharmacopoeia requires that 
it contain not less than 12 per cent nor more than 12.5 per cent of 
ciystallized morphine when assayed by the pharmacopoeial process; 
the powdered and deodorized opium are also required to contain this 
percentage of ciystallized morphine. 
The Tincture of Opium is now made from granulated opium instead 
of from powdered opium, as in the U. S. Pharmacopoeia, 1890. Much 
of the tincture of opium on the market seems to be under strength; 
it is hoped that a more uniform product will be obtained by- the use 
of granulated opium. 
Dose. — ‘‘Average dose: 0.065 Gm. = 65 milligrammes (1 grain).” 
(U. S. P.) 
