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SAFROLUM. 
Safrol. 
C 6 H 3 .C 3 H 5 .(OOCH,) 1:3:4 
“ The methylene ether of allyl pyrocatechol, found in oil of sassafras, 
camphor oil," etc. 
Properties. — A colorless, or faintly yellow, liquid with a sassafras- 
like odor. Soluble in about its own volume of strong alcohol and in 
about 30 volumes of 70 per cent alcohol. 
Safrol is contained to the extent of 80 per cent in the official oil of 
sassafras (Oleum Sassafras). Much of the safrol of commerce is 
obtained from camphor oil. Safrol is used to a considerable extent in 
flavoring drinks (sarsaparilla waters) and perfuming soaps. Heflter 
(Arch. f. exp. Path. u. Pharm., 35, p. 354) considers safrol to be the 
most poisonous of the volatile oils, and thinks its widespread use not 
unattended with danger. The effects of chronic poisoning are similar 
to those of yellow phosphorus. 
Dose. — “Average dose: 0.3 Cc. (5 minims)." (U. S. P.) 
SCOPOLA. 
Scopola. 
The dried rhizome of Scojiola carniolica, Jacquin (Fam. Solanacede). 
Scopola is closely related to Belladonna and Hyoscyamus. 
The Pharmacopoeia demands that the drug contain not less than 0.5 
per cent of alkaloids; it is assayed by the same process as are bella- 
donna leaves. 
Preparations admitted into the IT. S. Pharmacopoeia, Eighth Decen- 
nial Revision: Extract of Scopola and Fluidextract of Scopola (q. v.) 
Dose. — “Average dose: 0.045 Gm. = 45 milligrammes (f grain).” 
(U. S. P.) 
The alkaloid of Scopola is almost wholly hyoscyamine. The content 
of the alkaloids in Scopola is remarkably uniform (about 0.55 per 
cent), whereas the percentage of alkaloids in Belladonna varies from 
0.2 to above 1 per cent. 
There has been much discussion as to how far Scopola can replace 
Belladonna in therapeutics; its preparations are said to be used exten- 
sively in the manufacture of “belladonna plasters." 
SCOPOLAMIKE HYDROBROMIDOI. 
Scopolamine Hydrobromide. 
C 1T H 2 D'0 4 .HBr 4- 3H 2 0 
“The hydrobromide of an alkaloid obtained from plants of the Sol- 
anacede: chemicallv identical with Hvoscine Hvdrobromide." 
Although Hvoscine Hydrobromide. which was admitted into the 
U. S. Pharmacopoeia, 1890, and Scopolamine Hydrobromide are iden- 
