26 
Table showing the effect of alien serums upon guinea pigs sensitized with horse serum. 
Xo. of 
Kind and amount of 
normal serum. 
Previous treatment. 
guinea 
pig- 
Days 
prior. 
Inoculated subcutaneously with — 
Result. 
178 
Cattle, 6 c. c 
34 
2 i 0 c. c. donkey serum 
Symptoms, recovered. 
149 
do 
41 
0.22 c. c. toxine Xo. 7+ 3 a 0 c. c. horse 
serum (Steams 1351) . 
Do. 
180 
Hog, 6 c. c 
34 
2 i 0 c. c. donkey serum 
Xo symptoms. 
138 
do 
41 
0.22 c. c. toxine Xo. 7+ 3 i 0 c. c. horse 
serum (Stearns 1351) . 
Symptoms, recovered. 
4743 
Hog, 1 c. c 
41 
0.139 c. c. toxine Xo. 5-f- 3 4 0 c. c. horse 
serum (Alex. 192). 
Do. 
179 
Sheep, 6 c. c 
34 
2 i 0 c. c. donkey serum 
Do. 
152 
do 
41 
0.22 c. c. toxine Xo. 7-f 3 £ 0 c. c. horse 
serum (Steams 1351). 
Do. 
177 
Cat, 6 c. c 
34 
o i 0 c. c. donkey serum.. 
Do. 
124 
do 
41 
0.22 c. c. toxine Xo. 7-b 3 § c c. c. horse 
serum (Stearns 1351) . 
Xo symptoms. 
4744 
Cat, 1 c. c 
41 
0.139 c. c. toxine Xo. 5-f 3 i 0 c. c. horse 
serum (Alex. 192). 
Symptoms, recovered. 
121 
Rabbit, 6 c. c 
41 
0.22 c. c. toxine Xo. 7+ 3 £ 0 c. c. horse 
serum (Steams 1351). 
Do. 
4380 
do 
19 
0.22 c. c. toxine Xo. 7-f 2 4 0 c. c. horse 
serum (Xatl. V. 10). 
Do. 
4374 
do 
19 
0.22 c. c. toxine Xo. 7+j4 0 c. c. horse 
serum (Xatl. V. 7). 
Do. 
153 
Dog, 6 c. c 
41 
0.22 e. c. toxine Xo. 7+ 3 £ 0 c. c. horse 
serum (Steams 1351) . 
Do. 
4379 
. ....do 
19 
0.22 c. c. toxine Xo. 7+ 2 i 0 c. c. horse 
serum (Xatl. V. 10). 
D®. 
4742 
Dog, 1 c. c 
41 
0.139 c. c. toxine Xo. 7+ 3 i 0 c. c. horse 
serum (Alex. 192). 
Do. 
4375 
Guinea pig, 3 c. c . . . 
19 
0.22 c. c. toxine Xo. 7+ 2 i 0 c. c. horse 
serum (Xatl. V. 7). 
Xo symptoms. 
As the above series of guinea j)igs previously treated with horse 
serum showed unmistakable susceptibility to subsecpient injections 
of the blood serum of other animals, we are justified in saying that 
the action is not specific; but there is a very evident quantitative 
difference. It will be noticed that none of these guinea pigs died, 
and it was a matter of observation that, for the most part, they had 
characteristic but mild symptoms. 
T Ye next took up the question as to whether a guinea pig may be 
sensitized to horse serum with the blood serum of animals other than 
the horse. The following is a list of guinea pigs which had been 
treated by the subcutaneous inoculation of small quantities ( 2 } 0 c. c.) 
of blood serum from the rabbit, rat, donkey, cat, dog, hog, sheep, 
chicken, cattle, and man. Each pig was subsequently injected with 
6 c. c. of antitoxic horse serum (Xatl. IX. 17) into the peritoneal cavity. 
