78 
Neudorfer® refers to the fact that urticaria* frequently follows 
transfusion. 
Landois b also refers to this complication. 
In consequence of the severe injury which often resulted from the 
transfusion of lamb’s blood the practice was entirely discontinued. 
Recently, however, Dominici c has again taken up the subject. 
In England at one time the transfusion of milk was practiced, but 
proved dangerous and without benefit, as stated by Montard, Mar- 
tin, and Richet. (Injections intraveineuses de lait et de sucre, Soc. 
de Biol., 1879.) 
Latterly the transfusion of lamb’s blood has given place to phys- 
iological salt solution and also to the transfusion of defibrinated 
human blood. 
In the year 1894 the use of diphtheria antitoxin introduced the wide- 
spread practice of injecting horse serum. This practice differed from 
the previous work with transfusion in that the injections are generally 
not given intravenously, but subcutaneously, and the quantity of 
the alien albuminous substance is relatively small. According to 
von Pirquet and Schick this accounts partly for the fact that in the 
majority of these injections no injurious consequences followed. 
Luebinski (Uber eine Nachwirkung des Antitoxins bei Behandlung 
des Diphtherie, Deut. med. Woch., 1894) was the first to call attention 
to a case of exanthematous eruption following the injection of antitoxin 
serum. Soon afterwards Schiitz/ Cnyrim, * 6 Asch/ Rembold/ and 
Treymann h reported urticarial eruptions following the prophylactic 
injection of antitoxic horse serum. Following these came a great 
mass of evidence which made it clear that following the injection of 
antidiphtheric serum these sequelae were comparatively harmless. 
In relation to the cause of these symptoms it was generally held 
that the serum contained some toxic substance, probably a globulin. 
This explanation led manufacturers to the commendable practice of 
starving their horses about twenty-four hours prior to bleeding, in 
order to eliminate as far as practicable the freshly assimilated prod- 
ucts of digestion. 
a Neudorfer: Beitrage zur Bluttransfusion. Zeitschr. f. Chirurgie, Bd. 6. 
& Landois: Die Transfusion des Blutes, Leipzig, 1875. : Transfusion. Eulenburg’s 
Realencyclopadie, 3.Aufl., 1900. 
c Dominici: Transfusion. Wiener med. Wochenschr., 1895. 
d Schiitz: Discussionsbemerkung zu Piorkowski’s Vortrage. Berl. med. Geseirsch., 1904. 
e Cnyrim: Zwei Falle von Erkrankungen nach Anwendung des Diphtherieserums. Deut. 
med. Woch., 1894, p. 898. 
/Asch: Zur Casuistik der Heilserumexantheme. Berl. klin. Woch., 1894. . 
Q Remboid: Zwei Falle von Erkrankung nach Anwendung des Heilserums. Deut. med. 
W 7 och., 1894, p. 963. 
* Treymann, Otto: Ein Fall von acuterRamorrhagischer Nephritis nach Anwendung des 
Behring’schen Diphtherieheilserums. Deut. med. Woch., 1894, p. 952. 
