80 
Bujwid ° believed that these manifestations were due largely to 
fresh horse serum, and favors the use of old seasoned antitoxin for 
therapeutic purposes. 
Hamburger and Moro * * & have shown that the injection of alien 
serums into man result in the formation of precipitins. 
Hamburger/ in a further work, drew a distinction between ahen 
albuminous substances introduced through the digestive tract and by 
other channels. 
Upon the general toxic properties of blood we quote the following 
instances, taken largely from Uhlenhutk: d 
Stem/ 1S93. found that the blood from a case of erysipelas in 
amounts of 0.5 to 1 c. c. killed white mice, while normal human blood 
required 3 c. c. or more to kill the animals. 
Rummo/ 1891. showed that blood serum from cases of typhoid 
fever, malaria, pneumonia, and eclampsia had a high grade of toxicity 
for rabbits when injected intravenously. 
Albn/ 1897. confirm Rummo 's experiments, and found an increase 
of toxicity in persons suffering from pneumonia, severe chronic bron- 
chitis. epilepsy, uraemia, and puerperal sepsis. 
Upon the toxicity of the blood serum of man in health and disease 
further work has been done by Charrin/ Leclainche and Remond/ 
Chambrelent and Tamier. -’Ludwig and Savor. :; Guinard andDumarest. 
a Bujwid. O.: Kann des Antidiphtherieserum schadlick sein? Polnisch. ref. Virchow';? 
Jarhb., 1S97. II. p. 659. 
& Hamburger. F.. and Moro: Uber die biologischen nachweisbaren Verandert ungen des 
mensekliehen Biutes nacb Seruminjektion. Wiener klin. Woch.. 1903. 
c Hamburger. F.: Zur Frage der Immunisierung gegen Eiweiss. Wiener klin. Woch.. 
1902. : Arteigenheit und Assimilation. Wien. 1903. 
c L hlenbuth : Zur Kenntniss der giftigen Eigenscharten des Blutserums. Zeir. f. Hyg.. 
vol. 26. 1S97. p. 354. 
e Stem: Ueber einige Beziebungen zwiseben menseblieben Blutserum und pathogenen 
Bakterien. XII Congress fur innere Medic in. Wiesbaden. 1893): Deut. med. Woch.. 
1893. 
/Rummo: Ueber die Girtigkeit des Blutserums bei Menschen und Tnieren im normalen 
Zustande und bei Infectionskrankbeiten. Wiener med. Woch.. 1891. 
G Albu: Entersuchungen uber die Toxicitat normaler u. pathol. Serumflussigkeit . 
Virchow's Archiv. . bd. 140. 1897. 
- r - Charrin: Compt. rend. soc. biol.. 1890. 
; Leclainche and Remond: Compt. rend. soc. biol.. 1890. p. 1037. 
i Ludwig and Savor: Monatscbrift fur Geburtshulfe. bd. 1. 1895. 
Tamier and Chambrelent: Xote relative a la recherche de la toxicite du serum sanguin 
dans deux cas d'eclampsie puerperale. Soc. de biolog:. 1592. 
Gurnard and Dumarest: Xote sur la determination de la toxicite du serum sanguin: 
Techniques et resultats. Compt. rend.. 1897. Xo. 15. Variations de la toxicite du serum 
sanguin dans oertaines infections experiment ales. Loe. cit.. Xo. 18. A propos de la 
determination physiol, et clinique de la toxicite du serum humain. Loc. cit.. Xo. IS. 
