6 
The experimental production of true gastric ulcer, simulating the 
so-called peptic or round ulcer in man, has met with little success. The 
following table of experiments by previous investigators, taken from 
Turck's article upon ulcer of the stomach in the Journal of the Amer- 
ican Medical Association, volume 46, June 9, 1906, page 1753, gives in 
condensed form the method used to produce experimental gastric ulcer 
and results obtained: 
TABLES OF EXPERIMENTS BY PREVIOUS INVESTIGATORS. 
A. Mechanical and physical injury. 
Result. 
Ritter. Violent bruises. 
Decker. Heat Ulcer. 
Matthes. Trauma (with 5 per cent HC1) Ulcer. 
Schmidt. Trauma (with HCl). 
Korte. Pinching stomach with clamps Ulcer. 
B. Chemical. 
Roth. Crystals of nitrate of silver introduced into stomach Ulcer. 
1. HCl as a necessary factor. 
Riegel. HCl necessary. 
Matthes. Trauma (without HCl) Negative. 
Trauma (with 5 per cent HCl) Ulcer. 
Schmidt. HCl and trauma. 
Ewald. HCl essential factor. 
2. Contra HCl. 
Pawlow. Hyperacidity a consequence. 
Du Misinl. Superacidity without significance. 
Ageron. HCl may be persistently absent. 
Kavetsky. Synchronous ulcer of the stomach and bladder. 
. C. General dysemia. 
Virchow. Anemia and chlorosis. 
Quincke and Daetwyler. Anemia by producing gradual hem- 
orrhage and local trauma Ulcer, which healed 
with difficulty. 
Silbermann. Hemoglobinemia Ulcer. 
Futterer. Hemoglobinemia Ulcer. 
Cohnheim. Hemoglobinemia by mechanical injury and in- 
jection of laked blood Ulcers. 
D. Disturbance of local circulation. 
Virchow. Embolism, thrombi, aneurism, or varicose veins. 
Klebs and Welti. Thrombi. 
Panum. Injection of emulsion of wax into femoral vein Gastric infarcts, ulcer. 
Talma. Ligation of esophagus and pylorus Ulcer. 
Rindfleisch. Venous stasis; prolonged ischemia. 
Axel Key. Prolonged ischemia, due to contraction of gastric 
muscle No experiments. 
Muller. Tied portal vein Ulcer. 
