9 
The frequency with which guinea pigs, dead of diphtheria toxine, show the stomach lesion. 
Time of death. 
Less than 1 day 
Between 1 and 2 days 
Between 2 and 3 days 
Between 3 and 4 days 
Between 4 and 5 days 
Between 5 and 6 days 
Between 6 and 10 days 
More than 10 days 
Total 
Condition. 
Num- 
ber. 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
[Stomach 
lesion. . 
normal 
lesion. . 
normal 
lesion. . 
normal 
lesion., 
normal 
lesion. . 
normal 
lesion. . 
normal, 
lesion . . 
normal 
lesion. . 
normal 
[lesion. . 
[normal 
7 
6 
104 
61 
833 
235 
725 
254 
163 
144 
35 
85 
28 
84 
2 
116 
1,897 
985 
2, 882 
Lesions. 
Per cent. 
54 
62 
77 
73 
52 
28 
25 
1.7 
a 66 
a Average. 
CONTROLS. 
A number of comparisons were made with tetanus toxine and vari- 
ous chemical poisons, but in no instance was there found any similar 
sharply defined lesion in the pyloric extremity of the stomach. 
The stomachs of guinea pigs dead of tetanus toxine appeared quite 
normal. 
The stomachs of guinea pigs d}dng acutely from strong poisons, 
such as hydrocyanic acid, chloral cyanhydrin, etc., sometimes show 
acute hemorrhagic areas either of a diffuse or punctate nature, but in 
such cases the lesion is not confined to the pyloric end of the stomach. 
For the effect of various chemical poisons upon the stomach of guinea 
pigs we are indebted to Dr. Reid Hunt, Chief of the Division of Phar- 
macology, Hygienic Laboratory, for the following data upon animals 
used by him in other lines of research and which serve as our controls: 
Hydrocyanic acid. 
Five guinea pigs were given subcutaneously from 0.005 to 0.006 mg. 
of hydrocyanic acid per gram of guinea pig, which caused death in 
one hour fifteen minutes to six hours twenty-five minutes. 
G. P. No. 315 (0.005 rag.). Mucosa and submucosa of anterior and posterior walls 
of stomach showed large acute hemorrhagic areas. Pylorus apparently normal. 
G. P. No. 305 (0.0052 mg.). Stomach showed intense hemorrhage into the mucous 
membrane. Pylorus apparently normal. 
