CONTENTS. 
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Page. 
Introduction 7 
Part I: 
The sensitizing substance 11 
Part II: 
The toxic principle 15 
Influence of ferments 15 
Influence of alkaloids 16 
Influence of salts 16 
Influence of miscellaneous substances 17 
Influence of formaldehyd 17 
Influence of calcium chlorid 18 
Influence of freezing 21 
Part III: 
Is the toxic principle speciflc? 23 
Horse serum versus other proteid substances 23 
Other proteid substances versus horse serum 24 
Part IY: 
Other blood serums and other albuminous substances are also toxic 25 
Other blood serums 25 
Other albuminous substances 25 
PartY: 
Hypersusceptibility and immunity produced by bacterial proteids 31 
Part YI: 
Comparative toxicity of untreated and refined antitoxic serum 39 
Part YII: 
Comparative toxicity of different horse serums 43 
Toxicity of ‘ ‘ serum antidiphterique ’ ’ ( Pasteur Institute ) 43 
Toxicity of normal horse serum (our roan) 44 
Part YIII: 
The immunity to hypersusceptibility or “anti-anaphylaxis” 45 
Part IX : 
Maternal transmission of hypersusceptibility and immunity 47 
Group A, sensitized female, untreated male 47 
Group B, sensitized female, sensitized male 49 
Group C, immune female, immune male 50 
Group D, immune female, untreated male 52 
Group E, untreated female, sensitized male 54 
Conclusions 54 
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