9 
; half hours after the injection into the abdominal cavity. They were 
unable to demonstrate any protective properties in various organs of 
immune guinea pigs, confirming our work along the same lines. 
Nicolle ^ found that guinea pigs were not susceptible to the necrotic 
action induced by repeated injections of horse serum, as is the case in 
; rabbits; this corresponds with our observations. He also found that 
i daily injections or “spaced” injections, after the method of Arthus, 
. did not induce a high degree of hypersusceptibility in guinea pigs. 
1 } ■ Besredka^ questions whether we should not consider this toxic 
property of horse serum, as well as its antitoxic power. He suggests 
that a serum, 0.05 c. c. of which when given into the brain will kill 
i or cause grave symptoms in a sensitive guinea pig, should be 
considered as above the average toxicity and ought to be excluded 
I from use in man. 
,, The work of Otto^ on the “ Theobald Smith Phenomenon,” and of von 
^ Pirquet and Schick upon “the serum disease” has been previousl}" 
referred to. 
« Nicolle, Maurice: Contribution a 1’ etude du phenomene d' Arthus. Ann. de 
rinst. Pasteur, Vol. 21, No. 2, Feb. 25, 1907, pp. 128-136. 
^Besredka, A.: De la toxicite des serums therapeutiques et dumoyen de la doser. 
' Comp. rend. soc. biol., Vol. 62, No. 10, Mar. 22, 1907, pp. 477-478. 
' Otto, P. : Das Theobald Smithschen Phiinomen der Serum-Ueberempfindlichkeit. 
j V. Leuthold-Gedenkschr., Bd. 1, 
«^von Pirquet, C. Frh., and Schick, B.: Die Serumkrankheit. Leipzig and Wien, 
1905, 144 p. 8°. 
3681— No. 36—07 2 
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