Part IIL 
IS THE TOXIC PRINCIPLE SPECIFIC? 
The toxic action is quantitatively specific so far as various blood 
serums are concerned. That is, a guinea pig sensitized with horse 
serum is more susceptible to a subsequent injection of horse serum 
than to a subsequent injection of the blood serum of cattle, sheep, 
cats, dogs, hogs, etc. The specific character of the hypersuscepti- 
bility is more apparent when proteid substances of quite different 
origin are used at the first and second injections. For example, 
guinea pigs sensitized with horse serum do not react at all to subse- 
quent injections of peptone, vegetable proteid extracts, egg albumen 
or milk. 
Horse serum versus other proteid substances. 
No. 
G. P. 
First injection. 
Interval. 
Second injection. 
Result. 
Days. 
No symptoms. 
7030 
0.142 c. c. toxine 5-P 
elo c. c. antitoxic 
horse serum ( Ld. 4B ) , 
subcutaneously. 
52 
6 c. c. 3 per cent pep- 
tone, intraperitone- 
ally. 
7039 
0.142 c.' c. toxine 5+ 
yoVf c. c. antitoxic 
horse serum (Ld. 5H), 
subcutaneously. 
52 
do 
No symptoms. 
7038 
0.142 c. c. toxine 5+ 
c. c. antitoxic 
horse serum (Ld.5H), 
subcutaneously. 
52 
6 c. c. watery ex- 
tract of peas kept 
at 15° C. 24 hours, 
filtered through 
porcelain intraperi- 
toneally. 
No symptoms. 
7033 
0.142 c. c. toxine 5+ 
yfo c. c. antitoxic 
horse serum ( Ld. 34 ) , 
subcutaneously. 
52 
No symptoms. 
7036 
0.142 c. c. toxine 5+ 
xoVo c. c. antitoxic 
horse serum (Ld.5H), 
subcutaneously. 
52 
6 c. c. egg albumen, 
saturated solution 
in salt water (not 
filtered), intraperi- 
toneally. 
No symptoms. 
7041 
0.142 c. c. toxine 5+ 
7 ^^ c. c. antitoxic 
horse serum (Ld.5C), 
subcutaneously. 
52 
do 
No symj^toms. 
7032 
0.142 c. c. toxine 5+ 
5^0 c. c. antitoxic 
horse serum (Ld. 34), 
subcutaneously. 
52 
6 c. c. bottom milk 
unfiltered, intrape- 
ritoneally. 
No symptoms. 
i 
7035 
0.142 c. c. toxine 5+ 
8^0 c. c. antitoxic 
horse serum (Ld.5H), 
subcutaneously. 
52 
No symptoms. 
(23) 
