Part IV* 
OTHER BLOOD SERUMS AND OTHER ALBUMINOUS SUBSTANCES ARE 
ALSO TOXIC. 
So much of our work has been done with horse serum that we desire 
to record some further experiments with the blood serums of other 
animals. VTe confirm and extend our previous work that the same 
reactions may be induced in the guinea pig with the blood serums of 
various animals, such as the dog, ox, sheep, cat, and hog. 
Other Mood serums. 
Xo. 
G. P. 
First injection. 
Subcutaneously, 
c. c. serum of- 
461 
462 
463 
465 
466 
467 
468 
469 
470 
471 
472 
473 
474 
475 
476 
477 
478 
479 
480 
481 
482 
483 
484 
Ox 
do. 
do. 
....do. 
Sheep. . 
do. 
do. 
do. 
Hog... 
do. 
do. 
do. 
do. 
Dog ... 
do. 
do. 
do. 
do . 
Cat ... . 
do. 
do. 
do. 
485 ^ do 
Interval. Second injection. 
Result. 
1 
.5 0 
Iiitraperitone- 
ally, 6 c. c. se- 
Days. rum of — 
37 
Ox 
37 
do 
37 
do 
37 
do 
37 
Sheep . 
37 
do 
37 
do 
37 
do 
37 
do 
37 
Hog... 
37 
do 
37 
do 
37 
do 
37 
-do 
70 
Dog . . . 
70 
do 
70 
do 
70 
do 
70 
do 
70 
Cat . . . 
70 
do 
70 
do 
70 
do 
70 
do 
i 
Dead, 120 minutes. 
Marked symptoms. 
Severe symptoms. 
Severe symptoms. 
Slight symptoms. 
Dead, 110 minutes. 
Severe symptoms. 
Severe symptoms. 
Dead, 12 hours. 
Mild symptoms. 
Dead, 12 hours. 
Dead, 1 hour. 
Severe symptoms. 
Severe symptoms. 
Dead, 60 minutes. 
Dead, 120 minutes. 
Dead, 20 minutes. 
Dead, 65 minutes. 
Dead, 70 minutes. 
Dead, 120 minutes. 
Dead, 50 minutes. 
Dead, 120 minutes. 
Dead, 50 minutes. 
Dead, 65 minutes. 
OTHER ALBUMINOUS SUBSTANCES. 
As soon as we concluded that it is probably the proteid substance 
in horse serum that is chiefly concerned in sensitizing and poisoning 
the guinea pigs, we thought of other proteid substances obtained 
from widely different sources. 
VTe have found that hemoglobin, egg albumen, milk, and extract 
of peas are quite as active as horse serum. Peptone seems to have 
slight sensitizing and poisonous properties; leucin and t}’rosin none 
at all. The reaction following the second injection of proteid matter 
in the guinea pigs appears, then, to be common to all the higher 
forms of albuminous substances, no matter from what source. It 
occurs to us that this phenomenon of hypersusceptibility in the guinea 
pig may be used as a physiological test to distinguish true proteid sub- 
stances from the lower forms of nitrogenous compounds. It would 
3681— No. 36—07 4 (25) 
