41 
Comparative toxicity of untreated and refined antitoxic serum. 
No. 
G. P. 
First injection. 
Interval. 
Second injection. 
Result. 
0.142 c. c. toxine 5-i-qfo 
Days. 
7195 
41 
1 c. c. antitoxic 
Severe symptoms. 
c. c. antitoxic horse 
horse serum, Gib- 
serum (NYBH. 305), 
son precipitated 
subcutaneously. 
(NYBH. 305-6), 
subcutaneously. 
7190 
0.142 c. c. toxine 5-f 
Yobo c. c. antitoxic 
41 
do 
Severe symptoms. 
horse serum (NYBH. 
305), subcutaneously. 
7194 
0.142 c. c. toxine 54-g^-o 
41 
do 
Very severe symp- 
toms. 
c. c. antitoxic horse 
serum (NYBH. 305), 
subcutaneously. 
7189 
0.142 c. c. toxine 5+ 
41 
1 c. c. antitoxic 
Very severe symp- 
1 
i 
YoVo- c. c. antitoxic 
horse serum 
toms. 
horse serum (NYBH. 
(NYBH. 305-6), 
305 ) , subcutaneously. 
untreated. 
7193 
0.142 c. c. toxine 54 -^^ q- 
41 
do 
Very severe symp- 
toms. 
c. c. antitoxic horse 
i 
7196 
serum (NYBH. 305), 
subcutaneously. 
0.142 c. c. toxine S-f-gfo 
c. c. antitoxic horse 
41 
do 
Very severe symp- 
toms. 
serum (NYBH. 305), 
subcutaneously. 
We think it evident from the above that refined antitoxic serum 
precipitated and dialyzed in accordance with the Gibson method is 
quite as toxic, bulk for bulk, as the untreated serum from which it has 
been obtained. We must, however, consider that the treatment to 
which the serum is subjected in accordance with the Gibson method 
concentrates its antitoxic power about twice. There is, therefore, 
a distinct advantage gained, so far as bulk is concerned, in giving a 
corresponding number of antitoxic units; for, the serum reaction in 
children depends partly upon the quantity of serum given. 
