59 
r 
The removal of the thyroid gland or the spleen either before or 
after an injection of horse serum does not prevent the phenomenon of 
hypersusceptibility. 
It is of interest to note that the guinea pigs upon which splenectoni}^ 
was performed lost much hair and became reduced in weight, although 
the appetite seemed to remain good. 
THYROIDECTOMY. 
G. P, No. 7017. 0,142 c. c. toxine No. 5+^^^ c. c. antitoxic horse serum (Mem. 
A1103) , subcutaneously. 
55 days later, thyroid removed. 
80 days from sensitizing inoculation and 25 days after thyroidectomy, given 6 
c. c. normal horse (No. 15) serum, subcutaneously. Dead, 10 minutes. 
G. P. No. 7018. O. 142 c. c. toxine No. 5 +^q c. c. antitoxic horse serum (Mem. 
1103). 
55 days later, thyroid removed. 
125 days from sensitizing inoculation and 70 days after thyroidectomy, given 6 
c. c. normal horse (No. 15) serum, intraperitoneally. Dead, 30 minutes. 
G. P. No. X. Untreated. Thyroid removed. 
11 days after thyroidectomy, given 0.15 c. c. toxine No. 9 + 3 c. c. antitoxic 
horse serum (PD., 08516), subcutaneously. 
17 days after sensitizing inoculation and 28 days after thyroidectomy, given 6 
c. c. normal horse (No. 15) serum, intraperitoneally. Dead, 28 minutes. 
G. P. No. 425W. Untreated. Thyroid removed. 
11 days later, 0.15 c. c. toxine No. c. c. antitoxic horse serum (PD 
.08516).* 
69 days after sensitizing inoculation and 58 days after thyroidectomy, 6 c. c. 
normal horse (No. 15) serum, intraperitoneally. Dead, 5 minutes. 
SPLENECTOMY. 
G. P. No. 7044. 0.142 c. c. toxine No. 5 + 5 ^o c. c. antitoxic horse serum (Hb. 21A), 
subcutaneously. 
55 days later, spleen removed, 
80 days from sensitizing inoculation and 25 days after splenectomy, 6 c. c. nor- 
mal horse (No. 15) serum, intraperitoneally. Very severe symptoms. 
G. P. No. 7024. 0.142 c. c. toxine No. 5 + 2^0 c. c. antitoxic horse serum (Mem 
1103), subcutaneously. 
55 days later, spleen removed. 
80 days from sensitizing inoculation and 25 days after splenectomy, 6 c. c. nor- 
mal horse (No. 15) serum, intraperitoneally. Very severe symptoms. 
G. P, No. 3801V. Spleen removed. 
69 days later, 6 c. c. normal horse (No. 15) serum, intraperitoneally. No 
symptoms, 
G. P. No. XY. Spleen removed. 
11 days later, 0.15 c. c. toxine No. O-fg^o c. c. antitoxic horse serum (PD. 08516) , 
subcutaneou si 5 ^ . 
28 days after splenectomy and 17 days after sensitizing, 6 c. c. normal horse 
(No. ]5) serum, intraperitoneally. Severe symptoms. 
G. P. No. 410W. Spleen removed. 
11 days later, 0.15 c. c. toxine No. 9 + 3^0 c. c. antitoxic horse serum (PD. 08516), 
subcutaneously. 
58 days after sensitizing and 69 days after splenectomy, 6 c. c. normal horse 
(No. 15) serum, intraperitoneally. Marked symptoms. 
