CAN ANTITOXIN INFLUENCE E*IPHTHERITIC PARALYSIS WHEN 
INJECTED SHORTLY BEFORE THE PARALYSIS DEVELOPS? 
Tiie follo^ving tests sKow that the ad niirds tia tion of 4CH) tmits of 
anti toxin, given fifteen days after the injection of a partially neu- 
tralized dose of toxine and five to six days before paralysis appeared, 
can not control the appearance of the symptoms or save life. Fur- 
ther exr>erimental proof of this will be found in Tables Xos. 3 and 4. 
Guinea pigs X«os. 7930 and 7929 are illustrations of toxon poisoning 
with complete recovery. 
Tasl- N... -2.— THE EFFECT OY ANTITOXIN WHEN INJEcTEH .SHORTLY 
BEFORE .SYNIPT04IS .APPEAR. 
TIgXo. 
K-esoit. 
C -2-r C- C- TOI^Ttrr j 
C- ?7E^rE5 No. i v*i- 
Parsujsis yr.'z. day. 
Coriirr! . 
rpralsl, y. ZZ. lay. 
~?y. 
‘ : e. C- - : Nc-. 
: e. S-e.irr:s Vo. i m 
aziiitoxiii 1-3* n fay. 
= irfia 
Dc-ari. day. 
e. c. X. V. 5. ii- oIC- 
Par&Iyas AO-oziX 2^'z. diy. 
Co-Tr.3? . 
Ea:-*:'vere»i. 
X:-. 9 
c. c. X. y. B. H- 310. 
PaJT^ySS t'r'aall 
aHItTOlill 1-54 IL -lay. 
4J: irits 
P.anorei^d. 
7 iCc 
-- c. X->. 
e. r. X. Y- B. H- 3:C- 
PaTalys? '•eea:i at-oor Ir'id -Iat. 
IXaid. died d^y. 
?. c. X. T. E- H- 3;0- 
PaTSi.yS' -lay= 
x'~xixr‘xir. 25XZ. lay. 
-»X> anils 
Deaih. 2.5ti -day. 
c. e- X- y. B. H. -3:0. 
PauTiJyas *eeiLn y.r.~z day. 
C;*;r:4 . 
IXralh. -23i:i day. 
7/3-5 
e. c- i i X>. 
X. Y- B. H. 
Parslyds a'<*in 21 ?r ■lay= 
■ay. *.iri;s 
Dearr.. -day. 
HOW LONG .\FTER THE INFECTION C.\N ANTITO.XIN INFLUENCE 
P.\RALYSIS? 
A number :-f tests were undertaken to determine this important 
point. The first series of g^rinea pigs were all given an L — dose of 
toxine partially neutralized so that all of them, if untreated, as shown 
by the controls, would have developed paralysis between the thir- 
teenth and fourteenth days and died on the twentieth to the twenty- 
fifth day. 
Each grjinea pig in Table Xo. 3 received a mixmre containing 0.142 
c. c. of our toxine Xo. 9. which is the L— dose of this pwjison. plus 
c. c. of antitoxic horse serum. The minim al lethal dose of this 
toxine is O.Chj 6. Each guinea pig. therefore, received 24 minimal 
lethal doses. The toxine and antitoxin were mixed and allowed to 
