27 
In Table Xo. o, in which is shown the third series of guinea pigs 
given very large doses of antitoxin at varying times follovdng the 
subcutaneous inoculation of the toxine-antitoxin mixture, we find 
that only the three guinea pigs (Xos. 8183, 8184, and 8185) which 
received the antitoxin twenty-four hours after infection recovered. 
The paralysis in these tlmee pigs was so transient and slight m 
degree that its existence was open to some doubt in our minds, 
and is therefore not recorded m the table. 
TTe confess to some disappointment that the guinea pigs receivmg 
such massive doses of antitoxin as 4,000 units fort^^-eight hours 
after infection became paralyzed and died. (Xos. 8186, 8187, and 
8188.) Li Table Xo. 4 it appears that two of the three guinea pigs 
receiving repeated doses of antitoxin beginning forty-eight hours 
after infection recovered, and we were led to hope that one very 
large dose given forty-eight hours after infection would modify the 
paralysis more favorably than was actually the case vdth the 
guinea pigs m Table Xo. 5. This emphasizes more forcibly the 
importance of giving antitoxm early. It should be remembered 
that 4,000 units of antitoxin for a guinea pig weighing 250 grams 
is an enormous dose and would represent about 400,000 units for a 
50-pound child. 
