10 
Table No. 2. — Shovjing the results of the test (L+) dose of tetanus toxine A from Janu- 
ary 17, 1907, to April 7, 1908 — Continued. 
Guinea pig No. 
Weight 
in grama. 
Date. 
Amount of 
toxine A. | 
Amount of 
antitoxin. 
Time of 
death. 
400 
330 
Feb. 25,1907 
do 
Gram. 
0.0006 
' 
1 unit 
Days. Hours, 
4 21 
401 
315 
.0006 
1 unit 
5 7 
407 
335 
do 
.0006 
1 unit 
4 16 
408 
315 
do 
.0006 
1 unit . ... 
4 9 
415 . 
300 ' 
Mar. 5, 1907 
do 
. 0006 
1 unit. 
3 0 
41C 
325 * 
.0006 
1 unit 
3 10 
422 
300 
do 
.0006 
1 unit. 
3 9 
423 
325 
.. ..do 
.0006 
1 unit. 
3 10 
4.30 
*290 ' 
Mar. 22,1907 
.0006 * 
1 unit 
4 11 
431 
290 
do 
.0006 
1 unit 
4 14 
454 
300 
Mar. 28,1907 
.0006 
1 unit 
4 1 
300 
.do 
.0006 
1 unit. 
3 18 
509 
300 
Apr. 13,1907 
.0006 
1 unit 
3 17 
510 
295 
do 
.0006 
1 unit. 
3 17 
524 
280 
May 3,1907 
.0006 
' 1 unit 
3 18 
525 
290 
do 
• .0006 
1 unit 
3 11 
538 
300 
May 17,1907 
.0006 
1 unit 
3 20 
539 
320 
.do 
.0006 
1 unit. 
3 7 
556 
330 
May 24,1907 
.0006 
1 unit 
2 20 
557 .... 
350 
do 
.0006 
1 unit 
3 10 
615 
375 
July 28,1907 
.0006 
1 unit 
2 22 
616 
380' 
' do 
.0006 
1 unit 
3 10 
625 
350 
i 
July 31,1907 
.0006 
1 unit 
3 13 
626 
350 
1 ..do 
.0006 
1 unit. . . 
4 12 
639 
350 
' Sept. 6,1907 
. . . .do 
.0006 
1 unit 
3 4 
640 
350 
.0006 
1 unit 
3 2 
325 
Sept. 24, 1907 
.0006 
1 unit 
3 17 
370 
do 
.0006 
1 unit 
6 19 
679 
325 
Nov. 11,1907 
.0006 
1 unit 
3 19 
680 
350 
. .do 
.0006 
1 unit 
4 0 
683 . . 
350 
Dec. 7,1907 
do 
.0006 
• 1 unit. . . 
3 15 
684 
360 
.0006 
1 unit 
3 13 
702 
370 
Dec. 19,1907 
Apr. 7,1908 
do 
.0006 
1 unit. 
3 23 
757 
aio 
.0006 
1 unit 
4 1 
758 
a50 
.0006 
1 1 unit 
3 18 
759 
a5o 
1 do 
.0006 
; 1 unit 
4 0 
i 
NECESSITY FOR THIS STANDARD. 
We now know that when the symptoms of tetanus have developed 
the toxine has combined with the motor nerve cells and that the 
union between the cell and the poison is too strong for the antitoxin 
to break up. However, if the antitoxin is given in time the toxine 
is neutralized and rendered harmless. Tetanus antitoxin is there- 
fore an exceedingly valuable prophylactic and for this purpose is 
coming into more general use both in human and veterinary practice. 
Whether used as a proplndactic or curative agent it is important 
to use a potent serum. The law of July 1, 1902,“ not only insures 
