11 
serums of useful potency, but also establishes uniformity among 
the producers of tetanus antitoxin in America. The necessity of 
establishing uniformity for this product in American markets is evi- 
dent from the following table: 
Table No. 3. — Showing the differences in the methods of testing tetanus antitoxin before 
the adoption of the American unit. 
Name. 
Labeled. 
Con- 
tents 
(cubic 
centi- 
me- 
ters). 
Units 
claimed ac- 
cording to 
special 
methods of 
standard- 
ization, per 
cubic centi- 
meter. 
Units ac- 
cording to 
the Ameri- 
can stand- 
ard, per cu- 
bic centime- 
ter. 
New York department of health, Albany 
(submitted by Dr. H. D. Pease for com- 
One immunizing dose 
(No. 2929F). 
0.5 
434 
parison). 
New York City department of health (sub- 
mitted by Dr. W. H. Park for compari- 
700 
166 
son). 
H. K. Mulford Co. (bought on open mar- 
1,000,000 immunizing 
10 
100,000 
77 
ket). 
units (No. 2121). 
Farbenfabrik vorm. Meister Lucius & 
Tetanus Antitoxin, 
333 
Pruning, Hoechst, a/M (submitted for 
5 fach. Normal, 
comparative tests). 
Priifungs dose = 
1/500. 
H. K. Mulford Co., No. 9971 (submitted for 
tests). 
60,000,000 units 
10 
6,000,000 
90 
Parke, Davis & Co 
60, 000 
700 
New York department of health, All)any 
(submitted by Dr. H. D. Pease for com- 
.75 
769 
parison). 
Senun Antitetanique, Pasteur Institute, 
I^nit value not stated. 
10 
Not stated. 
40 
10 c. c. fluid. 
Serum Antitetanique, Pasteur Institute. . 
Tizzoni, Antitossina del Tetano, No. 2912, 
Dry. 
Unit value not stated. 
Unit value not stated. 
10 
Not stated. 
Not stated. 
40 
b83. 3 
Pasteur Ihstitute, , Serum antitetanique. 
Unit value not stated. 
10 
Not stated. 
66 
II-7. 
Institute Bacteriologique de Lyon et du 
Unit value not stated. 
10 
Not stated. 
(0 
Sud-Est. 
a Dissolved in 26. c. e. 
?> This equals 833 units per gram of the dry serum. 
c I.,ess than 50. 
Tetanus antitoxin is made by the following laboratories in the 
United States : 
Parke, Davis & Co., Detroit, Mich, (license No. 1); H. K. Mulford 
Company, Philadelphia, Pa. (license No. 2) ; Lederle Antitoxin 
a An act regulating the sale of viruses, serums, toxins, and analogous products, etc. 
Approved July 1, 1902. 
