CONTENTS? 
Part 1. The period of incubation 7 
Subcutaneous sensitization 8 
Intracerebral sensitization 8 
Relation of the amount of the sensitized dose to the time interval . 9 
Part 2. The sensitizing principle ]] 
The effect of heat upon the sensitizing action of horse serum 11 
Can guinea pigs be sensitized in the brain ? 12 
Guinea pigs may be sensitized in the eye 13 
Attempts to sensitize guinea pigs with pure proteids 13 
Effect of blood serum and brain substance 14 
Part 3. The toxic principle 15 
The effect of heat upon the toxicity of horse serum 15 
Does horse serum decrease in toxicity with age? 17 
The effect of various chemical substances upon the toxicity of 
horse serum 19 
Iodine 19 
Nitrites 22 
Ether 22 
Attempts to neutralize horse serum with the brain and blood of 
sensitized guinea pigs 23 
Part 4. Specificity 25 
The specific nature of anaphylactin 25 
Effect of iodine upon specificity 26 
Relation between milks of various species 26 
Human versus cow’s milk 26 
Sheep’s milk versus cow’s milk 27 
Dog milk versus cow’s milk 27 
Relation between egg albumins of varkus species 28 
Hen egg white versus duck egg white 28 
Duck egg white versus hen egg white 28 
Guinea hen egg white versus hen and crane egg white 29 
Pigeon egg white versus hen and crane egg white 29 
Goose egg white versus hen and turkey egg white 29 
Turkey egg white versus hen and crane egg white 30 
Part 5. Anaphylactin 31 
The presence of anaphylactin during the period of incubation. ... 31 
Anaphylactin in man and other animals 34 
Anaphylactin in immune guinea pigs 35 
Part 6. Mechanism 41 
Lesions found post-mortem in animals used in anaphylaxis 41 
( 5 ) 
