46 
injection of 1,000 units antidiphtheric serum. Site of inoculation 4 
inches above Poiipart’s ligament. Within two minutes had violent 
symptoms — anxious expression, itching, burning, labored breathing; 
lips, face, and neck swollen and red; paralysis; convulsions. Died 
within five mmutes of injection. 
The toxicity of this serum, i. e., another package of the same lab- 
oratoiy number, was tested upon the following series of guinea pigs: 
Table Xo. 38. — Toxicity of serum Xo. 2277. 
G.r. 
Xo. 
First injection. 
Inter- 
val in 
days. 
Second injection. 
Result. 
9147 
OJSe.c.toxine Xo.7-i-l/420c.c. 
antitoxic horse serum (PD. 
09913). 
97 
0.1 c. c. antitoxic horse serum 
(2277) into brain. 
Dead in 7 minutes. 
9131 
OJS c.c.toxine Xo. 7—1,250 c.c. 
antitoxic horse serum (Xatl. 
V.24). 
! 
, do 
Dead in S minutes. 
9136 
OJSc.c. toxine Xo. 7-1-1,300 c. c. 
antitoxic horse serum (Xatl. 
V. 24.) 
97 
0.05 c. c. antitoxic horse semm 
(2277) into brain. 
Dead in 35 minutes. 
9151 
0.23 c. c. toxine Xo. 7^1, 3S0c.c. 
antitoxic horse serum (PD. 
09491). 
O" 
Very severe symp- 
toms. 
9161 
OJ23 c.c.toxine Xo. 74-1320c.c. 
antitoxic horse serum t'Mem. 
C20). 
67 
2 c. c. antitoxic horse semm 
(2277) intraperitoneally. 
Dead in 3 hours. 
9170 
OJS c. c. toxine Xo. 7-!-l/330c. c. 
antitoxic horse serum (Mul. 
243S). 
67 
2 c. c. antitoxic horse semm 
(2277) subcutaneously. 
♦ 
Very severe s^tiii>- 
toms. 
Case Xo. 2 . — Serum Xo. 2295. Reported by Dr. H. F. Gillette, 
Cuba, X. Y., Joum. Am. Med. Assn., vol. 50, Jan. 4, 1908, p. 40. Mr. 
B., 52 years old. Had asthma and bronchial catarrh. Urine and 
heart normal. Rheumatic attack fifteen years prior. Coughed and 
raised plenty of sputum. Injection of 2,000 units antitoxic semm 
under left scapula. Prickling sensation in chest and neck; labored 
breathing; pulse regular and fidl. Seized vdth tonic spasm. Died 
within five minutes after injection. 
