49 
The following two serums were kindly furnished by Dr. E. M. 
Houghton, and were extensively used in human therapy, but no 
complaints were received concerning them: 
Table No. 42. — Comparative toxicity of serum No. 081 25 C. 
G. P. 
No. 
First injection. 
Inter- 
val in 
days. 
Second injection. 
Result. 
9635 
0.23 c. c. toxine No. 7+1/600 c.c. 
antitoxic horse serum (Alex. 
A249) subcutaneously. 
87 
0.05 c.c. antitoxic horse serum 
(PD 08725C) into the brain. 
Very severe symp- 
toms. 
9644 
0.23 c. c. toxine No. 7+1/680 c.c. 
antitoxic horse serum (Alex. 
A249) subcutaneously. 
87 
do 
Very severe symp- 
toms. 
9645 
0.23 c.c. toxine No. 7+1/660 c. c. 
antitoxic horse serum (Alex. 
A249) subcutaneously. 
87 
do 
Dead in 4 minutes. 
9632 
0.23 c.c. toxine No. 7+1/640 c. c. 
antitoxic horse serum (Alex. 
A249) subcutaneously. 
87 
0.05 c.c. antitoxic horse senim 
(PD 09043C) into the brain. 
Dead in 8 minutes. 
9646 
0.23 c. c. toxine No. 7+1/660 c.c. 
antitoxic horse serum (Alex. 
A249) subcutaneously. 
87 
do 
Dead in 4 minutes. 
9648 
0.23 c. c. toxine No. 7+ 1/640 c c. 
antitoxic horse serum (Alex. 
A249) subcutaneously. 
87 
do 
Dead in 15 minutes 
As a control, the following serums — some of them French anti- 
diphtheric and some normal horse serums — are given for compari- 
son: 
Table No. 43. — Comparative toxicity of French and other serums. 
G. P. 
No. 
First injection. 
Inter- 
val in 
days. 
Second injection. 
Result. 
532 
0.0006 c.c. tetanus toxine A+0.23 
c. c. antitoxic horse serum 
(Ehrlich standard). 
65 
0.25 c. c. normal horse (roan) 
serum into brain. 
Dead in 5 minutes. 
8497 
0.24 c.c. toxine No. 42+1/200 c. c. 
antitoxic horse serum (Cutter 
1828). 
18 
do 
Very severe symp- 
toms. 
8359 
0.24c. c. toxine No. 9+1/1260 c.c. 
antitoxic horse serum (N. Y. 
305). 
35 
Dead in 5 minutes. 
9550 
0.23 c. c. toxine No. 7+1/240 c.c. 
antitoxic horse serum (PD 
07635). 
62 
0.2 c. c. antistreptococcic se- 
rum (Past. Inst.) into 
brain. 
Dead in 3 minutes. 
9557 
0.23 c. c. toxine No. 7+1/280 c. c. 
antitoxic horse serum (Welc. 
2L839) . 
62 
Marked symptoms. 
9572 
0.23 c. c. toxine No. 7+1/260 c. c. 
antitoxic horse serum (Alex. 
A245). 
62 
Dead in 4 minutes. 
9580 
0.23 c. c. toxine No. 7+1/300 c.c. 
antitoxic horse serum (Alex. 
A245). 
65 
0.2 c. c. antitoxic horse serum 
(Lyons) into brain. 
Dead in 3 minutes. 
