81 
Martin, William, suggests that it would be desirable to make tests 
by selecting the crude drug and have liquid preparations made from 
this drug according to the pharmacopceial directions. As it is there 
is frequently no evidence to show the origin or the composition of the 
preparations tested. It has yet to be shown that there will be any 
variation of clinical importance if proper care is exercised by a 
competent pharmacist both in selecting the crude drugs and in 
making the preparation according to pharmacopceial directions. — 
Pharm. J., Lond., 1906, v. 22, p. 86. 
“ Gnomon," in discussing standardization extravagance, suggests 
that many of the preparations tested have probably been manufac- 
tured on the large scale by modifications of the official processes and 
kept for an unreasonable length of time or under improper condi- 
tions. — Ibid., v. 22, p. 88. 
Quant, Ernst, discussing the possibilities of physiological standardi- 
zation, points out that it would be advisable to consider the practi- 
cability of introducing standard methods of preparing and preserv- 
ing galencial preparations and believes that the perfecting of these 
methods would go far toward keeping the pharmacist free from the 
embarrassment of physiological standardization. — Ibid., v. 22, p. 98. 
Holmes, E. M., discusses the necessity for physiological standardi- 
zation and points out that it is very doubtful indeed if the methods 
of physiological testing now employed will serve to secure permanent 
uniformity of strength. — Ibid., v. 22, p. 126. 
Gaclcl, H. Wippel, discusses the economic questions involved in 
the physiological standardization of drugs and points out that, for 
the present at least, it would appear to be desirable for all who desire 
to see preparations of drugs made more efficacious to direct their 
efforts toward settling the methods by which this can be attained, 
leaving the economic questions to be settled in due course by ordinary 
laws of supply and demand. — Ibid., v. 22, pp. 149, 185. 
Grier, J., points out that the conditions under which physiological 
standardization must be conducted are too uncertain to warrant its 
adoption as an official method. A large series of experiments would 
have to be done before any definite conclusions concerning the value 
of any particular sample could be determined. — Ibid., v. 22, p. 238. 
McWalter, J. C., in discussing the bio-standardization of drugs, 
points out the desirability of determining the individual equation of 
the animal. — Chem. & Drug., Lond., 1906, v. 68, p. 204. 
Haynes, G. S., comments upon the unreliability of preparations of 
digitalis and declares the solution of the difficulty is to be found in 
physiological standardization of these drugs. Preparations should 
be placed on the market, suitably labeled, stating definitely that at a 
11667— Bull. 58—09 6 
