82 
given date a certain dose killed a frog of so many grammes within 
a limited time. — Biochem. J., Liverpool, 1906, v. 1, pp. 62-87. 
Focke agrees with Haynes that physiological control of the so- 
called 46 active principles," as well as the galenical preparations of the 
several heart tonics, is a practical necessity, and believes that future 
pharmacopoeias will include such requirements. — Therap. d. Gegenw. 
Berl., 1906, v. 47, pp. 348-351. 
Gunther (Tierarztl. Zentralbh, 1906) jmesents some observations 
on the relations existing between chemical composition and the action 
of medicinal substances. — Pharm. Post, Wien, 1906, v. 39, pp. 54-56. 
Maurel. E., concludes (1) the physiologic study of any agent should 
always commence with the fixation of the minimal mortal doses; 
(2) it is necessary to fix these doses for each species of animal and 
for each channel of administration utilized; (3) it is necessary to 
report the quantity employed per kilogramme of animal; finally (4) 
in describing the results obtained one should always indicate the 
quantity employed per kilogramme, the channel of administration 
utilized, and the minimum mortal dose by this channel. — Compt. 
rend. Soc. de biol. Par., 1906, v. 60, pp. 909, 975. 
Perrot. E.. discusses the therapeutic action of drugs and their active 
principles and points out that the latter do not accurately or even 
satisfactorily represent the therapeutic action of a satisfactory ex- 
tract of the crude drug. — Bull. gen. de therap. Par., 1906, v. 151, 
p. 447. 
Bacon. Raymond Foss, reports on the physiologically active con- 
stituents of certain Philippine medicinal plants, including dita bark 
( Alstonia scholaris ) , Datura alba , Entanda scandens , and a number 
of fish poisons used by the natives. — Philippine J. of Sci., 1906, v. 1. 
pp. 1007-1036. 
7. PHARMACEUTICAL PREPARATIONS. 
1. GENERAL FORMULAS. 
Searby. W. M., notes that the direction given by the Pharmacopceial 
Convention to adopt general formulas as far as possible does not seem 
to have been carried out to any great extent. As a consequence 56 
pages are taken up with processes for making fluid extracts, which 
would seem to be about 50 pages more than was really necessary. A 
general formula for preparing a few of these extracts would have 
sufficed: the menstruum to be employed in the making of the re- 
mainder is all that need have been given. — Am. J. Pharm., Phila., 
1906, v. 78, p. 213. 
Bougault, J., in discussing the U. S. P. VIII, notes that, with 
rare exceptions, one finds at the head of the different groups of 
medicaments no general indications as to mode of preparation, prin- 
