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ACETPHENETIDINUM. 
The Ph. Austr. VIII includes phenacetin as the synonym for acet- 
phenetidin, while the Ph. Belg. Ill uses phenacetinum as the title. 
The Council on Pharmacy and Chemistry mentions phenacetin as 
a name applied to acetphenetidin. — J. Am. M. Ass., 1906, v. 17, 
p. 1565. 
An editorial discusses the comparative price of phenacetin and 
acetphenetidin. — Ibid., v. 16. p. 598. 
An abstract (from Ztschr. f. analyt. Chem.) outlines a method of 
detecting acetanilide in phenacetin. 0.01 gm. of the suspected ma- 
terial is boiled for one minute with 1 c. c. of strong hydrochloric acid, 
then diluted with 10 c. c. of water, and filtered. The filtrate is then 
treated with 3 drops of a 3 per cent solution of chromic acid. If the 
phenacetin is pure a permanent ruby red color is obtained. If it con- 
tains acetanilide the color will be deep green and ultimately a pre- 
cipitate will be formed. — Pharm. J.. Lond., 1906, v. 22, p. 65. 
Riedel’s Berichte asserts that the melting point of phenacetin is 
uniformly 131° for a recrystallized, carefully dried material. In an 
air bath it melts at from 135.5 to 136° C. — Riedel’s Berichte, Berl., 
1906, p. 21. 
Lefeldt, Max, asserts that he has found the melting point of an 
otherwise excellent phenacetin to be 133°, and suggests that the varia- 
tion of the melting point be extended to read from 133 to 135° C. — 
Ber. d. pharm. Gesellscli., Berl., 1906, v. 16, p. 311. 
Mannich, C., describes a sample of phenacetin adulterated with 
parachloracetanilide and calls attention to the care that must be exer- 
cised by the pharmacist to regularly examine all medicinal substances 
for identity and purity. — Arb. a. d. pharm. Inst. d. Univ. Berl., 
1906, pp. 172-176. 
Gane, E. H., reports that phenacetin is occasionally adulterated 
with parachloracetanilide. Melting point 119 to 120° C. — Proc. 
Am. Pharm. Ass., 1906, v. 51, p. 311. 
Baird, J. TV, reports 31 samples examined in 1904, 5 adulterated. — 
Proc. Massachusetts Pharm. Ass., 1906, p. 59. 
An editorial discusses the reasons for the disrepute into which acet- 
anilide has fallen, largely owing to its indiscriminate use by the 
laity, and the substitution of phenacetin for acetanilide in popular 
remedies. Attention is called to the fact that while phenacetin is 
less toxic in equal amounts the effective dose of phenacetin is larger 
than that of acetanilide. — J. Am. M. Ass., 1906, v. 47, p. 1923. 
An editorial comments on a case reported by IV. TV Bell (Lancet), 
of a girl, 23 years of age, who took 125 grains of phenacetin and 10 
grains of antipyrine without fatal results. — Pharm. J., Lond., 1906, 
v. 23, p. 450. 
