162 
Zernik, F., records a comparative examination of the several 
mixtures of antipyrine, caffeine, and citric acid that are offered 
in Germany as headache cures. This mixture originated with 
Overlacli, who, in 1893, proposed such a mixture. (Deutsche. Med. 
Wchnschr., 1893, No. 47.) — Apoth. Ztg., Berl., 1906, v. 21, pp. 
673-674, 686-687. 
Jonescu, D., discusses the elimination of antipyrine from the human 
organism, and concludes that antipyrine is largely eliminated, un- 
changed, through the kidneys. Presents the literature on the sub- 
ject. — Ber. d. pharm. Gesellsch., Berl., 1906, v. 16, pp. 133-141. 
Fonteyne, A., finds that (1) respiration is accentuated from the 
first injection to the end of the experiment. (2) The volume of each 
respiration is increased with medium doses of 4.6 gm. followed by 
diminution and a fall to about normal depth with 16 gm. (3) The 
respiratory volume per minute follows the same fluctuation. — Arch, 
internat. cle pharmacod. et de therap., Par., 1906, v. 16, pp. 403—110. 
(See also “ General Conclusions,” Ibid., p. 449 ff.) 
Fonteyne gives a number of historical and pharmacologic refer- 
ences besides detailing his own researches. 
Valente (Ann. d’Oculist. March, 1905) has used antipyrine with 
good results in cases of optic atrophy following acute cerebral acci- 
dents, although it is of no value in simple, tabetic, toxic, or retro- 
bulbar cases. — Abstr. in Merck’s Archives, 1906, v. 8, p. 15. 
A correspondent calls attention to a patient in whom, on three 
occasions, antipyrine produced urticaria ; twice, the dose was 5 grains, 
the other time it was 10. — Chem. & Drug., Bond., 1906, v. 68, p. 899. 
Hotz, F. C., (Arch. Ophth., N. Y.) reports a case of antipyrine 
amaurosis induced by 130 grains taken in forty-eight hours. — J. Am. 
M. Ass., 1906, v. 47, p. 153. 
, APOCYNUM. 
Henkel, Alice, mentions Apocynum androscemi folium L., com- 
monly known as bitterroot, spreading dogbane, and honey -bloom, as 
being native in fields and thickets from Canada south to Georgia and 
Arizona. The most common species in Canada and the Northeastern 
States. 
Apocynum ccinnabinum L., commonly known as apocynum, Cana- 
dian hemp, black Indian hemp, and amy-root, is also mentioned. 
Native in moist ground and borders of fields throughout the United 
States. — Bui. Bur. Plant Ind., U. S. Dept. Agri., No. 89, 1906, p. 11. 
Schneider, Albert, points out that the fiber of Apocynum canna- 
binum L., is used by the Indians of California for making all man- 
ner of cordage, and for weaving, but that it apparently is not used 
medicinally. — Merck’s Rep., N. Y., 1906, v. 15, p. 65. 
