163 
Kraemer, H., asserts that a spurious root is being substituted for 
Apocynum. It has a circle of stone cells in the bark near the cam- 
bium. — Proc. Am. Pharm. Ass., 1906, v. 54, p. 333. 
Felter, Harvey Wickes, commenting on the description of the 
U. S. P., savs : 
Tlie indications for “Apocynum ” have been evolved from A. CannaMnum; 
therefore the pharmacopceial tincture is not likely to meet the object of the 
prescriber. — Eclectic Med. J., Cincin., 1906, v. 66, p. 234. 
Fyfe, John William, says that Apocynum cannobinum was then, 
as now, highly esteemed as a remedy in some forms of dropsy. It 
was also employed in indigestion, and the dose administered was 
“ as much as the stomach will bear." — Ibid., v. 66, p. 320. 
Heeve, William H., (Eclectic Rev.) reports marked benefit from 
apocynum in sciatica, after failure with many remedies. The classic 
indication — oedema at the ankle — led him to give it. This is not a 
common use of apocynum, though the indication is old and well 
tried. “ Dr. Heeve's success depended upon the recognition of the 
oedema, and not the sciatica, and this is what specific medication 
teaches.” — Abstr. Ibid., v. 66, p. 96. 
APOMORPHINE HYDORCHLORIDUM. 
The Ph. Brit. Committee of Reference in Pharmacy requires that 
apomorphine hydrochloride should be soluble in 4 (not 6) parts of 
water; 1 gram dissolves in 48 c. c. of 90 per cent alcohol. — Chem. & 
Drug., Lond., 1906, v. 69, p. 862. 
Dott, D. B., discusses the solubility of apomorphine hydrochloride 
as given by different authorities and points out that the U. S. P. 
figures, 1 in 39.5 parts of water at 25° C., are incorrect and that the 
statement should be 1 in 49 or thereby. — Pharm. J., Lond., 1906, 
v. 22, p. 345. 
Leffmau, Henry, comments on the rubric as an illustration of the 
excessive elaboration of tests. It gives the solubility of the salt in 
several liquids that would not be used for dissolving it in medical 
work, together with the melting and even the decomposing point, the 
latter certainly of little interest. Sixteen tests are given, several of 
them with unusual and expensive reagents, and almost all of them 
of interest and value only to the specialist in pharmaceutic chemistry 
and toxicology. — Am. J. Pharm., Phila., 1906, v. 78, p. 85. 
Pschorr, R., (Chem. Ber., 1906, v. 39, pp. 3124-3128) discusses the 
constitution of apomorphine and some of its derivatives. Biochem. 
Centralbl., Leipz., 1906-7, v. 5, p. 763. 
Herting, Otto, discusses the chemistry of apomorphine and its uses 
and calls attention to Euporphine, apomorphinbrommethylate, a de- 
rivative of apomorphine which is said to be less sensitive to the 
