179 
had been given 2 grammes each of extract and of powdered aspi- 
dium. — Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 802. 
ATROPINA. 
Riedel’s Berichte points out that while atropine sulphate will 
usually melt at 185° C. it is possible, by careful heating, to melt it 
at 180° C., while on rapid heating it requires 190° C. In an air bath 
the melting point is approximately 180° C. — Riedel’s Berichte, Berl., 
1906, p. 23. 
Utz asserts that atropine sulphate melts normally at from 185° to 
186° C. — Apoth. Ztg., Berl., 1906, v. 21, p. 930. 
Ipsen, C., discusses the possibility of demonstrating the presence 
of atropine and presents a number of conclusions on its resistance 
to putrefactive changes. — Ztschr. f. ang. Chem., Berl., 1906, v. 19, 
pp. 141-142. 
Doyon and Kareff (J. cle physiol, gen., 1906, v. 8, p. 227) reports 
some observations on the action of atropine on the coagulability of 
the blood. They find that atropine injected into the portal vein 
reduces the coagulability of the blood. Injection into the jugular 
or saphenous vein did not produce the same results. — Abstr. in 
Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 400. 
Lennancler, K. G., (Deutsch. Ztschr. f. Chim., Leip., v. 81, No. 1) 
states that we know too little of the action of atropine on the intestine 
for any rules for its use in peritonitis. — J. Am. M. Ass., 1906, v. 46, 
p. 1404. 
French, J. M., discusses at some length the physiological action and 
therapeutic indications and uses of atropine, laying stress upon the 
difference in action between small and large doses, antagonists and 
incompatibles, s}mergists and combinations. — Merck’s Archives, 1906, 
v. 8, pp. 35^0. 
Hewlett, A. W., is reported to have called attention to the fact that 
the use of atropine in connection with digitalis might possible stimu- 
late the bundle of His and prevent the occurrence of heart-block in 
cases when the use of digitalis is necessary. — J. Am. M. Ass., 1906, 
v. 47, p. 302. 
Modrakowski, G., (Pfhigers Arch., 1906, v. 114) reports some ob- 
servations on the action of atropine on the secretions of the pan- 
creas. — Biochem. Centralbl., Leipz., 1906-07, v. 5, p. 736. 
Zuelzer, G., (Therap. d. Geg., Berl., v. 47) advises the use of atro- 
pine in the treatment of asthma, since irritation of the vagus nerve 
experimentally produced expansion of the lung, which atropine 
relieves. — J. Am. M. Ass., 1907, v. 48, p. 462. 
Simon, J., reports some experiments on dogs to determine the 
degree of control exercised by atropine over the vomiting caused by 
morphine. — Arch. int. cle pharm. et de ther., 1906, v. 16, p. 225, 
