199 
derivatives obtained by reacting on this substance with many of the 
acid phenols through which the tannoid molecule is destroyed — pro- 
tocatechuic acid, gallic, and by extension the more simple of the 
series, salicylic acid. — Bull. des. sc. pharmacol., Par., 1906, v. 13, pp. 
613-616. 
Mirano, G. C., (Rif. med., 1906, v. 21, Xo. 38) finds that caffeine 
noticeably diminishes blood pressure (10 to 50 mm. Hg on the 
brachial), the cases of marked arteriosclerosis excepted. According 
to the author, it depends upon a diminution of peripheral resistance 
consequent upon vaso-dilation, in opposition to current opinion, and 
in circulatory disturbances caffeine acts favorably by increasing the 
power of the heart action. — Abstr. in. Biochem. Centrbl., Leipz., 
1906-7, v. 5, p. 205. 
Frey, Ernst, (Pfhigers Arch., v. 112, pp. 71-127) discusses the 
mechanism of caffeine diuresis. — Jahresb. u. Tier Chem. for 1906, 
Wiesb., 1907, v. 36, p. 326. 
Fraenkel. Albert, discusses the use of caffeine in the treatment 
of pneumonia, and points out some of the advantages that it 
possesses over digitalis. — Therap. d. Gegenw., Berl., 1906, v. 47, pp. 
1 - 6 . 
Gmeiner (Berl. tierartz. TCchnschr., 1906, Xo. 22, p. 409) com- 
mends the value of caffeine in pneumonia in veterinary practice. — 
Abstr. in Merck’s Ann. Rep. Darmstadt, 1906, v. 20, p. 68. 
Wells, G. Harlan, thinks caffeine ranks next to digitalis in im- 
portance as a cardiac tonic. He gives from 1 to 5 grains every 
three hours, by mouth, the maximum not to exceed 30 in twenty-four 
hours. He prefers the alkaloid to the so-called “ citrate.’* — Hahne- 
man. Month., Phila., 1906, v. 41, p. 260. 
CAFFEINA CITRATA. 
Taylor, S., saj 7 s this substance is stated to be equally successful if 
prepared with less water or even with no added water at all, the water 
in the citric acid being sufficient to effect combination. — Pharm. J., 
Lond., 1906, v. 23, p. 669. 
The Ph. Brit. Committee of Reference in Pharmacy report on caf- 
geine citrate says the formula and test require revision. — Chem. & 
Drug., Lond., 1906, v. 69, p. 863. 
CAFFEINE SODIO-BENZOAS N. F. 
Cambe, J., discusses the coloration that is evidenced in concentrated 
solutions of sodium benzoate with caffeine. He finds that the vel- 
lowish-green color only occurs in solutions containing impure caffeine 
or alkaline sodium benzoate. — Bull, pharm. du Sud-Est., 1906, v. 11, 
pp. 201-202. 
