227 
dispensed when chrysophanic acid is directed for external applica- 
tion. — Pharm. Zentralh., 1906, v. 47, p. 400. 
Krause (Zeitschr. f. Aughkde., 1906, v. 15, H. 3) reports that three 
patients with psoriasis developed, the one four weeks, both the other 
two five days after the beginning of chrysarobin therapy, a sub- 
epithelial corneal opacity with hypersemia of the iris and violent 
irritation and conjunctivitis. The phenomena disappeared on with- 
drawing the drug, to return promptly on renewal. Outcome finally 
favorable. — Abstr. in Biochem. Centralbl., Leipz., 1906-7, v. 5, p. 206. 
Bulkley, L. Duncan, mentions th^ fact that psoriasis of long stand- 
ing may be removed bv the use of chrysarobin, but the well-known 
disadvantages often preclude its use. — J. Am. M. Ass., 1906, v. 47, 
p. 1635. 
Nicolas and Favre (Lyon med., 1905, No. 46) think there is no 
need to avoid the occurrence of erythema in treating psoriasis by 
chrysarobin ; it is only necessary to regulate its extent and its 
severity. — Abstr. in Merck’s Ann. Rep., 1906, Darmstadt, 1907, v. 20, 
p. 79. ' 
CIMICIEUGA. 
Henkel, Alice, mentions Cimicifuga racemosa (L.) Nutt., also 
known as Actcea racemosa L., commonly known as cimicifuga, black 
snakeroot, squawroot, and rattle-root, as being found in rich soil in 
shady woods, Maine to Georgia, west to Wisconsin and Missouri. 
Most abundant in the Ohio Valley. — Bui. Bur. Plant Ind., L T . S. 
Dept. Agric. No. 89, 1906, p. 21. 
The Ph. Brit. Committee of Reference in Pharmacy is not in favor 
of an alcoholic extract assay for cimicifuga rhizoma. The section 
of the rhizome should be described and the ferric chloride test made 
with an infusion. — Chem. & Drug., Bond., 1906, v. 69, p. 863. 
Hommell, P. E., says one of the queries at present is, should not 
the present official tincture be discarded from the U. S. P. on account 
of the therapeutic antagonism of the alcohol and the drug content. 
He explains that this tincture is employed more as an antispasmodic 
diaphoretic, diuretic, and expectorant than a sedative. — Proc. New 
Jersey Pharm. Ass., 1906, p. 109. 
Shoemaker, John V., commends cimicifuga in chorea and quotes 
Hiram Corson's claim that he had used it for fifty years without a 
failure. — Merck’s Archives, 1906, v. 8, p. 174. 
Wells, G. Harlan, finds cimicifuga often of service in functional 
and organic heart diseases associated with nervous and rheumatic 
conditions. The indications for its use are irritability of the pulse, 
pain in the left mammary region, frontal headache, and, in Avomen, 
uterine or ovarian disturbances. — Hahneman Month., Pliila., 1906, 
v. 41, p. 264. 
